The results of stabilised hydrogen inhalations in patients with asthma
Smirnova MI, Antipushina DN, Gorshkov AYu, Strelkova AV, Ryzhakova LN, Emelyanov AV, Voinova SN, Ignatikova EN, Koshelyaevskaya YaN, Gufranov KF, Drapkina OM. · Russian Journal of Preventive Medicine. 2026;29(4):83–90.
What kind of evidence is this?
Human
Randomized double-blind controlled pilot study
Respiratory health
Inhaled H₂
No clear between-group clinical advantage.
Symptoms, function, cardiopulmonary tests, laboratory measures and safety.
Methods at a glance
Outpatients with uncontrolled or partly controlled asthma.
25 participants; H₂ group 17 and vapor-only group 8.
10 sessions, minimum eight, with follow-up at 28 days.
Stabilized H₂ with distilled-water vapor for 60 minutes daily.
Inhaled H₂-containing gas with water vapor.
At least 1% H₂; SUISONIA FRJ-220V device.
Device delivery as reported; a separate total flow was not stated.
No therapeutic oxygen co-delivery was reported.
The same water-vapor inhalation without the H₂-generating cartridge.
Outcomes and reported result
Asthma control, six-minute walk, dyspnea/exertion scales, spirometry, ECG, echocardiography, inflammation and adverse events.
Both groups improved on asthma control and walking distance; no between-group differences were found for the main clinical and functional measures, and adverse events were mild.
The full article methods, intervention, outcomes, positive and null findings, funding and conflict statements were checked.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Very small 2:1 pilot, multiple outcomes and limited power; within-group changes should not be read as superiority.
The reported outpatient asthma population and protocol only.
Cochrane RoB 2 — preliminary
Some concerns
Randomization and double blinding were reported, but the very small imbalanced groups and multiple outcomes create imprecision and reporting concerns.
Random sequence reported or described · Allocation concealment not fully established · Deviations and co-interventions checked · Outcome measurement checked by endpoint · No outcome-level protocol comparison completed
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
DOI: 10.17116/profmed20262904183 · DOI: 10.17116/profmed20262904183
A free publisher or repository full article was checked.
Publisher or repository full article and bibliographic record; checked 10 August 2026.
2026-08-10