Effect of acute hydrogen-rich water intake on intraocular pressure in healthy subjects
Najmanová E et al. · Cesk Slov Oftalmol. 2023;79(4):180–184.
Study at a glance
Human
Healthy adults aged 20–33 years
1,260 mL hydrogen-rich water consumed in three 420 mL doses over 15 minutes · 0.9 ppm dissolved H₂; reported pH 7.8.
Acute observation through 75 minutes
Both waters increased intraocular pressure from baseline. Group-level IOP values did not differ significantly, but clinically significant individual increases occurred in 58% after H₂ water versus 25% after placebo; corneal thickness did not change.
Small healthy-volunteer acute study. The group-level comparison was null, while a potentially adverse IOP signal appeared in individual responses; people with glaucoma were not studied.
What kind of evidence is this?
Human
Randomized double-blind placebo-controlled crossover study
Eye health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Healthy adults aged 20–33 years
24 participants: 5 men and 19 women
Acute observation through 75 minutes
1,260 mL hydrogen-rich water consumed in three 420 mL doses over 15 minutes
H₂ dissolved in water — H₂ only, not Brown’s gas.
0.9 ppm dissolved H₂; reported pH 7.8.
1,260 mL H₂-free placebo water; median crossover interval 7 days
Outcomes and reported result
Intraocular pressure and central corneal thickness
Both waters increased intraocular pressure from baseline. Group-level IOP values did not differ significantly, but clinically significant individual increases occurred in 58% after H₂ water versus 25% after placebo; corneal thickness did not change.
Dose, methods and results checked in the free publisher full text; funding and independent appraisal remain incomplete.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Small healthy-volunteer acute study. The group-level comparison was null, while a potentially adverse IOP signal appeared in individual responses; people with glaucoma were not studied.
Healthy young adults after rapid ingestion; safety in glaucoma, ocular hypertension or suspected glaucoma remains untested.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 37567773 · DOI: 10.31348/2023/23
The publisher provides a free full-text article.
Free publisher full text and PubMed bibliographic record.
10 August 2026
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