Hydrogenology
Hydrogenology editorial study record

Effect of acute hydrogen-rich water intake on intraocular pressure in healthy subjects

Najmanová E et al. · Cesk Slov Oftalmol. 2023;79(4):180–184.

HumanH₂-rich waterPublished 2023
Study record, not medical adviceThis page reports one source and Hydrogenology’s source-text extraction. It does not establish that molecular hydrogen is effective, safe or appropriate for any person. Human, animal and laboratory evidence must not be treated as equivalent.
Source and classification

What kind of evidence is this?

Evidence stream

Human

Reported design

Randomized double-blind placebo-controlled crossover study

Research topic

Eye health

Administration classification

H₂-rich water

Study result signal

Not reported in this record.

Outcome type

Not reported in this record.

Reported in the source

Methods at a glance

Population or model

Healthy adults aged 20–33 years

Sample

24 participants: 5 men and 19 women

Duration

Acute observation through 75 minutes

Intervention

1,260 mL hydrogen-rich water consumed in three 420 mL doses over 15 minutes

Hydrogen form

H₂ dissolved in water — H₂ only, not Brown’s gas.

H₂ specification

0.9 ppm dissolved H₂; reported pH 7.8.

H₂ flow

Not applicable — oral water, not gas inhalation.

O₂ delivered with H₂

No O₂ was co-delivered as part of the intervention.

Comparator

1,260 mL H₂-free placebo water; median crossover interval 7 days

Reported, not endorsed

Outcomes and reported result

Outcomes measured

Intraocular pressure and central corneal thickness

Reported result

Both waters increased intraocular pressure from baseline. Group-level IOP values did not differ significantly, but clinically significant individual increases occurred in 58% after H₂ water versus 25% after placebo; corneal thickness did not change.

Results-extraction completeness

Dose, methods and results checked in the free publisher full text; funding and independent appraisal remain incomplete.

A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.

Interpretation limits

Cautions and applicability

Design and reporting cautions

Small healthy-volunteer acute study. The group-level comparison was null, while a potentially adverse IOP signal appeared in individual responses; people with glaucoma were not studied.

Applies directly to

Healthy young adults after rapid ingestion; safety in glaucoma, ocular hypertension or suspected glaucoma remains untested.

Preliminary appraisal framework

Not reported in this record.

Preliminary risk-of-bias status

Not reported in this record.

Appraisal rationale

Not reported in this record.

No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.

Provenance

Sources and record status

Identifiers

PMID: 37567773 · DOI: 10.31348/2023/23

Publisher access

The publisher provides a free full-text article.

Extraction basis

Free publisher full text and PubMed bibliographic record.

Record revision

2026-08-10

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