Silicon-based agent mitigates fatty liver formation in a CDAHFD60-induced MASH mouse model by enhancing hepatic function.
Koyama Y, Kobayashi Y, Hirota I, Kobayashi H, Shimada S. · Biochemistry and Biophysics Reports. 2026;46:102552.
What kind of evidence is this?
Preclinical
Randomized controlled mouse study
Metabolic and lipid health
Other forms
Mixed positive preclinical signal.
Tissue, histological and biomarker outcomes in an animal model.
Methods at a glance
Male C57BL/6J mice fed a CDAHFD60 diet to model metabolic dysfunction-associated steatohepatitis.
26 mice; 13 per diet group after a two-week induction period.
12 weeks of intervention after two weeks of model induction.
CDAHFD60 diet containing 2.5% of a silicon-based hydrogen-generating agent.
Hydrogen generated in the gastrointestinal tract by a silicon-based dietary agent; not Brown's gas.
The study evaluated a hydrogen-generating material rather than a measured dose of dissolved or inhaled H2.
Not applicable — dietary agent.
No oxygen was co-delivered.
The same CDAHFD60 diet without the silicon-based agent.
Outcomes and reported result
Liver histology, hepatic and serum lipids, oxidative-stress measures and biochemical markers.
The supplemented group had less hepatic steatosis and favorable changes in several lipid and oxidative-stress measures; not every measured endpoint differed between groups.
The full article, methods, figures and positive and null findings were checked.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Animal evidence only. The intervention is a hydrogen-generating silicon product, so effects cannot automatically be assigned to molecular hydrogen alone.
The reported CDAHFD60 mouse model only.
SYRCLE animal-study tool — preliminary
Some concerns
Small animal study with reported randomization, but allocation concealment and assessor blinding were not established from the article.
Randomization/allocation reporting is limited · Blinding of personnel is unclear · Attrition is incompletely reported in places · Blinding of outcome assessors is unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 41890216 · DOI: 10.1016/j.bbrep.2026.102552
Free full article in PubMed Central.
PubMed record and PubMed Central full text; extraction checked 9 August 2026.
2026-08-10