Hydrogen-rich saline treatment modulates proteomic profiles to mitigate cataract development in a N-methyl-N-nitrosourea-induced rat model
Qu Y, Li X, Yang Q, Li R, Tao Y, Huang Y, Wang L. · International ophthalmology. 2026;46(1):63.
Molecular hydrogen (H2) and Metabolic and lipid health
Browse 72 source-checked metabolic and lipid health records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.
72full-text-checked records
18human studies
54animal and laboratory records
No treatment conclusion is impliedGlucose regulation, lipid measures, clinical outcomes and safety are not treated as interchangeable. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Hydrogen‐Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via Promoting Mitophagy
Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y, Ni Q, Ding X, Song G. · Journal of diabetes. 2026;18(4):e70209.
Long-Term Consumption of Hydrogen-Rich Water Mitigates Oxidative Stress, Hepatic Inflammation, and Apoptosis in Rats with LPS-Induced Chronic Liver Injury
Zhang L, Wang H, Mai Y, He Q, Liu T, Zhang N, Zhang J. · Antioxidants (Basel, Switzerland). 2026;15(2):260.
Silicon-based agent mitigates fatty liver formation in a CDAHFD60-induced MASH mouse model by enhancing hepatic function.
Koyama Y, Kobayashi Y, Hirota I, Kobayashi H, Shimada S. · Biochemistry and Biophysics Reports. 2026;46:102552.
Application of Molecular Hydrogen in Early Heart Failure Development: Modulation of Microcirculation, Metabolism, Oxidative Stress, and Myocardial Status
Deryugina AV, Danilova DA, Polozova AV. · Antioxidants (Basel, Switzerland). 2025;14(12):1418.
DGKζ in Glycerophospholipid Metabolism Regulates the DAG and PA Balance and Interacts With PTEN to Alleviate Brain Damage in Septic Mice With Hydrogen Inhalation: A Comparative Metabolomic and Phosphoproteomic Analysis
Bai Y, Li Z, Yan D, Jiang Y, Dong B, Yu Y. · Brain and behavior. 2025;15(8):e70761.
Effects of 12-Week Hydrogen-Rich Water Consumption on Body Composition and Metabolic Biomarkers in Adults with Metabolic Syndrome Stratified by Breath Hydrogen Levels: A Randomized Controlled Trial
Todorović N, Nedeljkovic D, Korovljev D, et al. · Current Topics in Nutraceutical Research. 2025;23(2):29–38.
Hydrogen gas (H_2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction–associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis
Chen Y, Wang K, Guo W, Lu C, Suo W, Li Q, Deng Y, Chen X, Dai M, Zhang X, Xu J, Su W, Yang S, Yang H, Yan F, Liu H, Zhang Y. · Frontiers in pharmacology. 2025;16:1575106.
Long-term administration of hydrogen-rich water enhances quality of life in diabetic rats and reduces renal neoplasm incidence through modulation of inflammatory and metabolic pathways
Chen Q, Yu S, Pan Y, Tang H, Wang Y, Feng N, Wu H, Yu G. · Translational andrology and urology. 2025;14(6):1765-1781.
Long-Term Neuroprotective Effects of Hydrogen-Rich Water and Memantine in Chronic Radiation-Induced Brain Injury: Behavioral, Histological, and Molecular Insights
Xu K, Liu H, Wang Y, He Y, Liu M, Lu H, Wang Y, Niu P, Qin X. · Antioxidants (Basel, Switzerland). 2025;14(8):948.
Molecular Hydrogen as an Adjuvant Therapy in Comorbid Sjögren’s Syndrome, SLE, and ILD: A Case Report on Immune Modulation and Fatigue Reduction
Tsai YH, Lu JW, Tu JI, Li YJ, Hsu HF, Chang FH, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In vivo (Athens, Greece). 2025;39(4):2228-2235.
Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism
Tian Y, Su H, Chen Y, Geng X, Zhang Y, Wang Y, Tang W, Fan W, Zhou J, Wei Y. · Molecular biology reports. 2025;52(1):751.
Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study
Grepl P et al. · Med Gas Res. 2025;15(3):367–373.
Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells
Yu P, Hong N, Wu Q, Zhao Z. · Endocrine, metabolic & immune disorders drug targets. 2025;25(14):1177-1190.
The augment effects of magnesium hydride on the lipid lowering effect of atorvastatin: an in vivo and in vitro investigation.
Chen W, Zhang Y, Miao G, Ying Y, Ren Z, Sun X, Cai J, Shen H, Lu H. · Medical Gas Research. 2025;15:47.
The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial
Todorovic N et al. · Medicina (Kaunas). 2025;61(7):1299.
Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial
Wu F et al. · Heliyon. 2024;10(16):e36401.
Health Effects of Electrolyzed Hydrogen Water for the Metabolic Syndrome and Pre-Metabolic Syndrome: A 3-Month Randomized Controlled Trial and Subsequent Analyses
Moribe R, Minami M, Hirota R, et al. · Antioxidants. 2024;13(2):145.
Hydrogen gas improves proliferation and mitochondrial activity of human adipose-derived stem cells after cryopreservation
Kimura K, Tabata Y. · Regenerative therapy. 2024;26:571-577.
Hydrogen-Rich Water (HRW) Reduces Fatty Acid-Induced Lipid Accumulation and Oxidative Stress Damage through Activating AMP-Activated Protein Kinase in HepG2 Cells
Tsou SH, Lin SC, Chen WJ, Hung HC, Liao CC, Kornelius E, Huang CN, Lin CL, Yang YS. · Biomedicines. 2024;12(7):1444.
Oral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice
Sugiyama R, Hanaguri J, Yokota H, Kushiyama A, Kushiyama S, Kikuchi T, Igarashi T, Iketani M, Ohsawa I, Harino S, Nakashizuka H, Yamagami S, Nagaoka T. · Translational vision science & technology. 2024;13(10):36.
A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases
Tao G, Liu F, Jin Z, Liu B, Wang H, Li D, Tang W, Chen Y, He Q, Qin S. · Theranostics. 2023;13(8):2455-2470.
Effect of molecular hydrogen treatment on Sepsis‐Associated encephalopathy in mice based on gut microbiota
Han Q, Bai Y, Zhou C, Dong B, Li Y, Luo N, Chen H, Yu Y. · CNS neuroscience & therapeutics. 2023;29(2):633-645.
Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study
Chiu SH, Douglas FL, Chung JR, Wang KY, Chu CF, Chou HY, Huang WC, Wang TY, Chen WW, Shen MC, Liu FC, Hsiao PJ. · Frontiers in nutrition. 2023;10:1198524.