Effects of 12-Week Hydrogen-Rich Water Consumption on Body Composition and Metabolic Biomarkers in Adults with Metabolic Syndrome Stratified by Breath Hydrogen Levels: A Randomized Controlled Trial
Todorović N, Nedeljkovic D, Korovljev D, et al. · Current Topics in Nutraceutical Research. 2025;23(2):29–38.
Study at a glance
Human
Adults with metabolic syndrome stratified by baseline breath hydrogen below or above 10 ppm.
1,000 mL/day hydrogen-rich water in three 330 mL servings for 12 weeks. · Each tablet-prepared serving produced approximately 5 mg dissolved H₂; approximately 15 mg/day across three servings.
12 weeks.
A time-by-treatment interaction was reported for waist circumference (p=0.02); experimental groups changed by -2.2±1.8 and -2.4±2.0 cm. No severe adverse events were reported; one mild transient diarrhea event occurred.
Small four-arm sample with five non-completers. Tablets were supplied by Natural Wellness Now Health Products. The article's flow-diagram wording calls the study a crossover trial although the methods describe a parallel design; Hydrogenology preserves this inconsistency.
What kind of evidence is this?
Human
Randomized double-blind placebo-controlled parallel four-arm study
Metabolic and lipid health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Adults with metabolic syndrome stratified by baseline breath hydrogen below or above 10 ppm.
40 randomized, 10 per arm; 35 completed. Mean age 51.2±7.9 years; 27 women.
12 weeks.
1,000 mL/day hydrogen-rich water in three 330 mL servings for 12 weeks.
H₂ dissolved in drinking water — H₂ only, not Brown's gas.
Each tablet-prepared serving produced approximately 5 mg dissolved H₂; approximately 15 mg/day across three servings.
Matched placebo tablets containing the same reported magnesium amount, stratified by baseline breath-hydrogen category.
Outcomes and reported result
Body composition, waist circumference, metabolic biomarkers, breath hydrogen and adverse events.
A time-by-treatment interaction was reported for waist circumference (p=0.02); experimental groups changed by -2.2±1.8 and -2.4±2.0 cm. No severe adverse events were reported; one mild transient diarrhea event occurred.
The free journal full article, four-arm methods, results, adverse events and acknowledgements were checked.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Small four-arm sample with five non-completers. Tablets were supplied by Natural Wellness Now Health Products. The article's flow-diagram wording calls the study a crossover trial although the methods describe a parallel design; Hydrogenology preserves this inconsistency.
Adults with metabolic syndrome under the reported 12-week protocol.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
OpenAlex ID: W7148627714 · DOI: 10.37290/ctnr.v23i2.29
Free journal full article.
Journal full article; full-text extraction checked 8 August 2026.
10 August 2026
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