Long-term administration of hydrogen-rich water enhances quality of life in diabetic rats and reduces renal neoplasm incidence through modulation of inflammatory and metabolic pathways
Chen Q, Yu S, Pan Y, Tang H, Wang Y, Feng N, Wu H, Yu G. · Translational andrology and urology. 2025;14(6):1765-1781.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Metabolic and lipid health
H₂-rich water
Not reported in this record.
Not reported in this record.
Methods at a glance
rats, rat, cells, cell used to study metabolic and lipid health.
Preclinical study; the full text reports 14 rats, with group/assay counts including n=6, n=8, n=5.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water. No numeric quantity is inferred beyond the source wording.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
The full article describes the H₂ intervention but does not report a numeric H₂ concentration.
Not applicable — no inhaled H₂ intervention was identified in the full article.
No inhaled O₂ co-delivery was identified for this non-inhalation intervention.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “However, ITT results showed that the FBG levels in the DM rats without HRW treatment were significantly increased compared with those in the HRW-treated…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 40687659 · DOI: 10.21037/tau-2025-314
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10