Hydrogenology
Hydrogenology editorial study record

The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial

Todorovic N et al. · Medicina (Kaunas). 2025;61(7):1299.

HumanH₂-rich waterPublished 2025
Study record, not medical adviceThis page reports one source and Hydrogenology’s source-text extraction. It does not establish that molecular hydrogen is effective, safe or appropriate for any person. Human, animal and laboratory evidence must not be treated as equivalent.
Source and classification

What kind of evidence is this?

Evidence stream

Human

Reported design

Randomized double-blind placebo-controlled trial

Research topic

Metabolic and lipid health

Administration classification

H₂-rich water

Study result signal

Not reported in this record.

Outcome type

Not reported in this record.

Reported in the source

Methods at a glance

Population or model

Men and women with obesity

Sample

36 participants; 24 women

Duration

8 weeks

Intervention

Hydrogen-rich water, 1.0 L/day containing 15 mg H₂

Hydrogen form

H₂ dissolved in water — H₂ only, not Brown’s gas.

H₂ specification

15 mg H₂/day in 1.0 L water.

H₂ flow

Not applicable — oral water, not gas inhalation.

O₂ delivered with H₂

No O₂ was co-delivered as part of the intervention.

Comparator

1.0 L/day control water containing 0 mg H₂

Reported, not endorsed

Outcomes and reported result

Outcomes measured

Appetite and cravings, body composition, sleep, quality of life, lipids, GLP-1 and short-chain fatty acids

Reported result

Between-group p values were 0.05 for cravings, sleep and GLP-1, 0.02 for total cholesterol and 0.04 for LDL. No major body-composition or quality-of-life differences were observed; no severe adverse effects were reported.

Results-extraction completeness

Methods, main results, registration and conflict statement checked in the free full text; independent appraisal remains incomplete.

A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.

Interpretation limits

Cautions and applicability

Design and reporting cautions

Small study with many outcomes and several p values exactly at the 0.05 threshold. Alex Tarnava was employed by the company that supplied the tested supplements.

Applies directly to

Adults with obesity meeting this trial’s criteria.

Preliminary appraisal framework

Not reported in this record.

Preliminary risk-of-bias status

Not reported in this record.

Appraisal rationale

Not reported in this record.

No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.

Provenance

Sources and record status

Identifiers

PMID: 40731927 · DOI: 10.3390/medicina61071299

Publisher access

Open-access article.

Extraction basis

Free full text on PMC and publisher page; identifiers cross-checked in PubMed.

Record revision

2026-08-10

Open bibliographic source ↗Open lawful free full text ↗Open trial registry ↗Report a discrepancy