The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial
Todorovic N et al. · Medicina (Kaunas). 2025;61(7):1299.
Study at a glance
Human
Men and women with obesity
Hydrogen-rich water, 1.0 L/day containing 15 mg H₂ · 15 mg H₂/day in 1.0 L water.
8 weeks
Between-group p values were 0.05 for cravings, sleep and GLP-1, 0.02 for total cholesterol and 0.04 for LDL. No major body-composition or quality-of-life differences were observed; no severe adverse effects were reported.
Small study with many outcomes and several p values exactly at the 0.05 threshold. Alex Tarnava was employed by the company that supplied the tested supplements.
What kind of evidence is this?
Human
Randomized double-blind placebo-controlled trial
Metabolic and lipid health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Men and women with obesity
36 participants; 24 women
8 weeks
Hydrogen-rich water, 1.0 L/day containing 15 mg H₂
H₂ dissolved in water — H₂ only, not Brown’s gas.
15 mg H₂/day in 1.0 L water.
1.0 L/day control water containing 0 mg H₂
Outcomes and reported result
Appetite and cravings, body composition, sleep, quality of life, lipids, GLP-1 and short-chain fatty acids
Between-group p values were 0.05 for cravings, sleep and GLP-1, 0.02 for total cholesterol and 0.04 for LDL. No major body-composition or quality-of-life differences were observed; no severe adverse effects were reported.
Methods, main results, registration and conflict statement checked in the free full text; independent appraisal remains incomplete.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Small study with many outcomes and several p values exactly at the 0.05 threshold. Alex Tarnava was employed by the company that supplied the tested supplements.
Adults with obesity meeting this trial’s criteria.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 40731927 · DOI: 10.3390/medicina61071299
Open-access article.
Free full text on PMC and publisher page; identifiers cross-checked in PubMed.
10 August 2026
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