Administration route

Inhaled molecular hydrogen research

Browse 184 source-checked molecular hydrogen records classified as inhaled hydrogen, with human and preclinical evidence separated.

184full-text-checked records

63human studies

121animal and laboratory records

No treatment conclusion is impliedAdministration routes, concentrations, doses and treatment schedules vary and must not be treated as interchangeable. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.

HumanInhaled H₂2026

A randomized controlled double-blind study on the brain protection of infantile patients with epileptic spasm syndrome through atomized inhalation of hydrogen-oxygen gas

Chen C, He W, Chen J, Shi XY, Yang G, Wang J, Wang YY, Hu PL, Han F, Meng Y, Zou LP. · Frontiers in Neurology. 2026;17:1781738.

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PreclinicalInhaled H₂2026

Comparison of hydrogen administration methods in the treatment of radiation-induced heart disease in rats

Kura B, Pavelkova P, Kalocayova B, Sykora M, Vlkovicova J, Kluknavsky M, LeBaron T, Pobijakova M, Sagatova A, Slezak J. · Can J Physiol Pharmacol. 2026;104:1–13.

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HumanInhaled H₂2026

Effect of hydrogen–oxygen inhalation on sleep disorders and abnormal mood: a single-blind, randomized controlled trial

Gao YH et al. · Med Gas Res. 2026;16(2):98–102.

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PreclinicalInhaled H₂2026

Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress

Xiao K, Li M, Mu Y, Sun Y, Wang S, Chen S, Ma J, Cao M, Yang Y, Shao H, Ding X, Cui G, Du Z. · Frontiers in Bioengineering and Biotechnology. 2026;13:1668524.

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HumanInhaled H₂2026

Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation

Moriya M, Oyama K, Den Y, Yamada Y, Sakatani K. · Scientific reports. 2026;16(1):6202.

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HumanInhaled H₂2026

Long-term survival in patients with primary malignant brain tumors after postoperative home hydrogen inhalation: Three case reports

Xu KC, Kong XF, Qian W, Liang B, Li DG, Korpan NN. · World Journal of Clinical Cases. 2026;14(20):121466.

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PreclinicalInhaled H₂2026

Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice

Hori F et al. · Int J Mol Sci. 2026;27(2):635.

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PreclinicalInhaled H₂2026

Molecular Hydrogen Modulates the Baroreflex Activity and Reduces the Vascular Adrenoreceptor Sensitivity to Phenylephrine and Lung Inflammation in Rats with Pulmonary Hypertension

Artemieva M, Kozaeva L, Kuropatkina T, Gufranov K, Atiakshin D, Medvedeva N, Medvedev O. · Biomedicines. 2026;14(3):494.

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HumanInhaled H₂2026

Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females

Grepl P et al. · Can J Physiol Pharmacol. 2026;104:1–9.

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HumanInhaled H₂2026

The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome

Pozdnyakova DD, Baranova IA, Selemir VD, Medvedev OS, Chuchalin AG. · Ter Arkh. 2026;98(3):147–153.

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HumanInhaled H₂2026

The effect of stabilized hydrogen inhalation on clinical and functional parameters in patients with chronic obstructive pulmonary disease

Antipushina DN, Smirnova MI, Gorshkov AYu, Strelkova AV, Ryzhakova LN, Emelyanov AV, Voinova SN, Ignatikova EN, Koshelyaevskaya YaN, Gufranov KF, Drapkina OM. · Russian Journal of Preventive Medicine. 2026;29(6):58–67.

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HumanInhaled H₂2026

The results of stabilised hydrogen inhalations in patients with asthma

Smirnova MI, Antipushina DN, Gorshkov AYu, Strelkova AV, Ryzhakova LN, Emelyanov AV, Voinova SN, Ignatikova EN, Koshelyaevskaya YaN, Gufranov KF, Drapkina OM. · Russian Journal of Preventive Medicine. 2026;29(4):83–90.

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HumanInhaled H₂2025

Alleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes

Zhang X, Lu X, Li F, Gu H, Cheng X, Tang J, Zhang X, Jiang J, Feng L, Li X. · Journal of thoracic disease. 2025;17(8):6151-6162.

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PreclinicalInhaled H₂2025

Application of Molecular Hydrogen in Early Heart Failure Development: Modulation of Microcirculation, Metabolism, Oxidative Stress, and Myocardial Status

Deryugina AV, Danilova DA, Polozova AV. · Antioxidants (Basel, Switzerland). 2025;14(12):1418.

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HumanInhaled H₂2025

Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy

Liu B, Bao Y, Ma J, Wang X, Feng Y. · Advances in radiation oncology. 2025;10(11):101879.

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HumanInhaled H₂2025

Complementary Therapies of Diabetic Peripheral Neuropathy and Intermittent Claudication

Ng SY. · 2025.

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PreclinicalInhaled H₂2025

DGKζ in Glycerophospholipid Metabolism Regulates the DAG and PA Balance and Interacts With PTEN to Alleviate Brain Damage in Septic Mice With Hydrogen Inhalation: A Comparative Metabolomic and Phosphoproteomic Analysis

Bai Y, Li Z, Yan D, Jiang Y, Dong B, Yu Y. · Brain and behavior. 2025;15(8):e70761.

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HumanInhaled H₂2025

Effect of hydrogen inhalation on functional characteristics and intestinal gas biomarkers in wrestlers during physical exercise

Medvedev OS, Uzhakov AA, Konnova OL, Povarova OV. · Sports Medicine: Research and Practice. 2025;15(2):20–30.

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PreclinicalInhaled H₂2025

Efficacy of a hydrogen–oxygen generator in treating cigarette smoke–induced chronic obstructive pulmonary disease in rats

Huang WT, Cheng TJ, Huang LH, Hou YT. · Current Research in Toxicology. 2025;8:100214.

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HumanInhaled H₂2025

Efficiency and safety of the integrated use of medical gases thermal heliox, nitric oxide and molecular hydrogen in patients with exacerbation of chronic obstructive pulmonary disease complicated by hypoxemic, hypercapnic respiratory failure and secondary pulmonary arterial hypertension in the post-COVID period

Shogenova LV. · Ter Arkh. 2025;97(3):242–249.

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HumanInhaled H₂2025

Fatigue disappearance in hemodialysis patients by dual approach with hydrogen gas inhalation and hydrogen-enriched dialysate: two case reports

Nakazawa R, Nagami S, Nozaki H, Yataka M, Akiyama K, Uchino T, Azuma N. · Medical Gas Research. 2025;15(1):59–61.

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PreclinicalInhaled H₂2025

Hydrogen gas inhalation ameliorates glomerular enlargement after hypoxic-ischemic insult in asphyxiated piglet model

Iwaki T, Nakamura S, Wakabayashi T, Nakao Y, Htun Y, Tsuchiya T, Mitsuie T, Koyano K, Morimoto A, Fuke N, Yokota T, Kondo S, Konishi Y, Miki T, Ueno M, Iwase T, Kusaka T. · Scientific reports. 2025;15(1):1677.

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HumanInhaled H₂2025

Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial

Maruyama T et al. · Biomedicines. 2025;13(8):1799.

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PreclinicalInhaled H₂2025

Hydrogen inhalation and intrathecal magnesium sulfate ameliorate ischemia by suppressing cortical spreading depolarization in a rat subarachnoid hemorrhage model

Yoshiura T, Kawauchi S, Nishida S, Sato S, Hagita D, Endo A, Nakagawa M, Fujii T, Otsuka Y, Mishima Y, Fujii K, Takeuchi S, Tomiyama A, Toyooka T, Sato S, Wada K. · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2025;22(5):e00617.

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