Gas composition matters
H₂ delivered alone, diluted in air or supplied with oxygen describes different exposure conditions. Concentration and co-delivered gases should be reported explicitly.
Inhaled molecular hydrogen research
Inhaled molecular hydrogen research: 185 source-checked studies (63 human; 122 preclinical). Compare delivery, outcomes and limitations.
Choose an evidence group to browse its records. Start with the molecular hydrogen research overview.
How to interpret molecular hydrogen inhalation research
The 185 records in this collection include 63 human and 122 preclinical studies involving inhaled molecular hydrogen. Exposure conditions differ across sources: H₂ concentration, gas mixture, flow, delivery system, session duration, treatment frequency and safety controls must all be examined separately.
Delivery and duration matter
Masks, cannulas, chambers and other systems may produce different exposure patterns. A short experimental session is not equivalent to repeated or prolonged use.
Safety context matters
Hydrogen is flammable. Engineering controls and validated equipment are separate from questions about biological or clinical outcomes.
No treatment conclusion is impliedH₂ concentration, gas mixture, delivery system, flow, duration and treatment schedules vary and must not be treated as interchangeable. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
A randomized controlled double-blind study on the brain protection of infantile patients with epileptic spasm syndrome through atomized inhalation of hydrogen-oxygen gas
Chen C, He W, Chen J, Shi XY, Yang G, Wang J, Wang YY, Hu PL, Han F, Meng Y, Zou LP. · Frontiers in Neurology. 2026;17:1781738.
Comparison of hydrogen administration methods in the treatment of radiation-induced heart disease in rats
Kura B, Pavelkova P, Kalocayova B, Sykora M, Vlkovicova J, Kluknavsky M, LeBaron T, Pobijakova M, Sagatova A, Slezak J. · Can J Physiol Pharmacol. 2026;104:1–13.
Effect of hydrogen–oxygen inhalation on sleep disorders and abnormal mood: a single-blind, randomized controlled trial
Gao YH et al. · Med Gas Res. 2026;16(2):98–102.
Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress
Xiao K, Li M, Mu Y, Sun Y, Wang S, Chen S, Ma J, Cao M, Yang Y, Shao H, Ding X, Cui G, Du Z. · Frontiers in Bioengineering and Biotechnology. 2026;13:1668524.
Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation
Moriya M, Oyama K, Den Y, Yamada Y, Sakatani K. · Scientific reports. 2026;16(1):6202.
Long-term survival in patients with primary malignant brain tumors after postoperative home hydrogen inhalation: Three case reports
Xu KC, Kong XF, Qian W, Liang B, Li DG, Korpan NN. · World Journal of Clinical Cases. 2026;14(20):121466.
Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice
Hori F et al. · Int J Mol Sci. 2026;27(2):635.
Molecular Hydrogen Modulates the Baroreflex Activity and Reduces the Vascular Adrenoreceptor Sensitivity to Phenylephrine and Lung Inflammation in Rats with Pulmonary Hypertension
Artemieva M, Kozaeva L, Kuropatkina T, Gufranov K, Atiakshin D, Medvedeva N, Medvedev O. · Biomedicines. 2026;14(3):494.
Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females
Grepl P et al. · Can J Physiol Pharmacol. 2026;104:1–9.
The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome
Pozdnyakova DD, Baranova IA, Selemir VD, Medvedev OS, Chuchalin AG. · Ter Arkh. 2026;98(3):147–153.
The effect of stabilized hydrogen inhalation on clinical and functional parameters in patients with chronic obstructive pulmonary disease
Antipushina DN, Smirnova MI, Gorshkov AYu, Strelkova AV, Ryzhakova LN, Emelyanov AV, Voinova SN, Ignatikova EN, Koshelyaevskaya YaN, Gufranov KF, Drapkina OM. · Russian Journal of Preventive Medicine. 2026;29(6):58–67.
The results of stabilised hydrogen inhalations in patients with asthma
Smirnova MI, Antipushina DN, Gorshkov AYu, Strelkova AV, Ryzhakova LN, Emelyanov AV, Voinova SN, Ignatikova EN, Koshelyaevskaya YaN, Gufranov KF, Drapkina OM. · Russian Journal of Preventive Medicine. 2026;29(4):83–90.
Alleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes
Zhang X, Lu X, Li F, Gu H, Cheng X, Tang J, Zhang X, Jiang J, Feng L, Li X. · Journal of thoracic disease. 2025;17(8):6151-6162.
Application of Molecular Hydrogen in Early Heart Failure Development: Modulation of Microcirculation, Metabolism, Oxidative Stress, and Myocardial Status
Deryugina AV, Danilova DA, Polozova AV. · Antioxidants (Basel, Switzerland). 2025;14(12):1418.
Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
Liu B, Bao Y, Ma J, Wang X, Feng Y. · Advances in radiation oncology. 2025;10(11):101879.
Complementary Therapies of Diabetic Peripheral Neuropathy and Intermittent Claudication
Ng SY. · 2025.
DGKζ in Glycerophospholipid Metabolism Regulates the DAG and PA Balance and Interacts With PTEN to Alleviate Brain Damage in Septic Mice With Hydrogen Inhalation: A Comparative Metabolomic and Phosphoproteomic Analysis
Bai Y, Li Z, Yan D, Jiang Y, Dong B, Yu Y. · Brain and behavior. 2025;15(8):e70761.
Effect of hydrogen inhalation on functional characteristics and intestinal gas biomarkers in wrestlers during physical exercise
Medvedev OS, Uzhakov AA, Konnova OL, Povarova OV. · Sports Medicine: Research and Practice. 2025;15(2):20–30.
Efficacy of a hydrogen–oxygen generator in treating cigarette smoke–induced chronic obstructive pulmonary disease in rats
Huang WT, Cheng TJ, Huang LH, Hou YT. · Current Research in Toxicology. 2025;8:100214.
Efficiency and safety of the integrated use of medical gases thermal heliox, nitric oxide and molecular hydrogen in patients with exacerbation of chronic obstructive pulmonary disease complicated by hypoxemic, hypercapnic respiratory failure and secondary pulmonary arterial hypertension in the post-COVID period
Shogenova LV. · Ter Arkh. 2025;97(3):242–249.
Fatigue disappearance in hemodialysis patients by dual approach with hydrogen gas inhalation and hydrogen-enriched dialysate: two case reports
Nakazawa R, Nagami S, Nozaki H, Yataka M, Akiyama K, Uchino T, Azuma N. · Medical Gas Research. 2025;15(1):59–61.
Hydrogen gas inhalation ameliorates glomerular enlargement after hypoxic-ischemic insult in asphyxiated piglet model
Iwaki T, Nakamura S, Wakabayashi T, Nakao Y, Htun Y, Tsuchiya T, Mitsuie T, Koyano K, Morimoto A, Fuke N, Yokota T, Kondo S, Konishi Y, Miki T, Ueno M, Iwase T, Kusaka T. · Scientific reports. 2025;15(1):1677.
Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial
Maruyama T et al. · Biomedicines. 2025;13(8):1799.
Hydrogen inhalation and intrathecal magnesium sulfate ameliorate ischemia by suppressing cortical spreading depolarization in a rat subarachnoid hemorrhage model
Yoshiura T, Kawauchi S, Nishida S, Sato S, Hagita D, Endo A, Nakagawa M, Fujii T, Otsuka Y, Mishima Y, Fujii K, Takeuchi S, Tomiyama A, Toyooka T, Sato S, Wada K. · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2025;22(5):e00617.