Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China
Ji H, Sun H, Zhang Y, Zhao Z, Gao X, Wang C, Yang Y, Zhang X, Gao J, Man D, Yang Q, Yang Y, Yue C, Chen C, Ding X, Ni T. · Frontiers in cardiovascular medicine. 2024;11:1391282.
Study at a glance
Human
Human participants studied for cardiovascular and circulatory health. See eligibility criteria in the linked full text.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 2.0 L/min, 140 mm, 90 mm. · H₂-related quantities reported in the intervention passages: 2.0 L/min, 140 mm, 90 mm. Values are not combined across different experimental arms.
2.0 L/min
Article-reported result excerpt (24 words maximum): “The SBP levels decreased in HI group (−5.93 mm Hg; 95% CI, −7.30 to −4.57) and control group (−1.31 mm Hg; 95% CI, −2.61…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Prospective human study
Cardiovascular and circulatory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for cardiovascular and circulatory health. See eligibility criteria in the linked full text.
Human study; the full text reports 126 patients, with group/assay counts including n=1, n=305.
2.0 L/min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 2.0 L/min, 140 mm, 90 mm.
Inhaled molecular H₂; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 2.0 L/min, 140 mm, 90 mm. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Placebo or matched control reported in the full article.
Outcomes and reported result
clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “The SBP levels decreased in HI group (−5.93 mm Hg; 95% CI, −7.30 to −4.57) and control group (−1.31 mm Hg; 95% CI, −2.61…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this cardiovascular and circulatory health article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39600611 · DOI: 10.3389/fcvm.2024.1391282
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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