Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.
Liu C, Lu JW, Wu CH, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In Vivo. 2026;40:14220.
What kind of evidence is this?
Human
Case report
Cardiovascular and circulatory health
Other forms
Indeterminate for molecular hydrogen.
Clinical course and immune biomarkers in a single patient.
Methods at a glance
One patient with systemic lupus erythematosus-associated pulmonary arterial hypertension receiving ongoing medical care.
1 patient.
Longitudinal follow-up reported in the case article.
One oral hydrogen-generating capsule daily as an adjunct to existing therapy.
Hydrogen generated after ingestion of a capsule; not Brown's gas.
The capsule contained 170 mg hydrogen-enriched coral calcium; the article states an estimated hydrogen-generating capacity rather than a measured systemic dose.
Not applicable — oral capsule.
No oxygen was co-delivered.
No control; clinical course before and after adjunctive use.
Outcomes and reported result
Clinical course and regulatory and effector lymphocyte measurements.
The report describes clinical stability and changes in selected immune-cell measures after adjunctive capsule use.
The full case report, timeline, measurements and concomitant treatments were checked.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
A single uncontrolled case with concomitant treatment cannot establish that hydrogen caused the observed course or biomarker changes.
This individual case only.
JBI Case Report Checklist — preliminary
Serious concerns
No comparator and substantial confounding from disease course and concurrent therapy.
Single selected case · Co-interventions were present · Follow-up described in the report · Several outcomes were clinician- or patient-reported · No prespecified analysis plan
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 41482388 · DOI: 10.21873/invivo.14220
Free full article in PubMed Central.
PubMed record and PubMed Central full text; extraction checked 9 August 2026.
2026-08-10