Cardiovascular research

Molecular hydrogen (H2) and Cardiovascular and circulatory health

Browse 74 source-checked cardiovascular and circulatory health records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.

74full-text-checked records

17human studies

57animal and laboratory records

No treatment conclusion is impliedClinical events, vascular function, symptoms and biomarkers are kept distinct. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.

HumanOther forms2026

Adjuvant Molecular Hydrogen Therapy in SLE-associated Pulmonary Arterial Hypertension: A Case Report on Immunomodulatory Effects on Regulatory and Effector Lymphocytes.

Liu C, Lu JW, Wu CH, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In Vivo. 2026;40:14220.

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PreclinicalInhaled H₂2026

Comparison of hydrogen administration methods in the treatment of radiation-induced heart disease in rats

Kura B, Pavelkova P, Kalocayova B, Sykora M, Vlkovicova J, Kluknavsky M, LeBaron T, Pobijakova M, Sagatova A, Slezak J. · Can J Physiol Pharmacol. 2026;104:1–13.

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PreclinicalInhaled H₂2026

Molecular Hydrogen Modulates the Baroreflex Activity and Reduces the Vascular Adrenoreceptor Sensitivity to Phenylephrine and Lung Inflammation in Rats with Pulmonary Hypertension

Artemieva M, Kozaeva L, Kuropatkina T, Gufranov K, Atiakshin D, Medvedeva N, Medvedev O. · Biomedicines. 2026;14(3):494.

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HumanInhaled H₂2026

Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females

Grepl P et al. · Can J Physiol Pharmacol. 2026;104:1–9.

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HumanInhaled H₂2025

Complementary Therapies of Diabetic Peripheral Neuropathy and Intermittent Claudication

Ng SY. · 2025.

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PreclinicalInhaled H₂2025

Hydrogen inhalation therapy alone may not alleviate intestinal mucosal damage in NOMI without total‐layer necrosis: An experimental swine model study

Tanaka Y, Matsumura Y, Hayashi Y, Aoki M, Izawa Y, Endo K, Mato T. · Acute medicine & surgery. 2025;12(1):e70072.

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PreclinicalOther forms2025

Hydrogen rescues vascular endothelial cells in obstructive sleep apnea-hypopnea syndrome by modulating nitric oxide

Chen Q, Jiang D, He J, Sun M. · Journal of thoracic disease. 2025;17(11):9598-9609.

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HumanOther forms2025

Molecular Hydrogen as a Potential Adjunctive Therapy to Improve Renal Function and Reduce Fatigue in an Elderly Patient With Chronic Comorbidities: A Case Report

Lin YT, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In vivo (Athens, Greece). 2025;39(1):572-576.

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HumanOther forms2025

Molecular Hydrogen as an Adjuvant Therapy in Severe Lupus Serositis With Heart Failure: A Case Report on Immune Modulation and Fatigue Reduction

Lin YT, Lu JW, Ho YJ, Lui SW, Hsieh TY, Liu HC, Wang KY, Liu FC. · In vivo (Athens, Greece). 2025;39(2):1200-1206.

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HumanOther forms2025

Molecular Hydrogen Therapy for SLE‐PAH: Case Report on Immune Marker Modulation

Tu TH, Lu JW, Wu CH, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In vivo (Athens, Greece). 2025;39(2):1211-1219.

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PreclinicalOther forms2025

Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs

Shibuya M, Fujinaka M, Yonezawa M, Nishimura N, Uchinoumi H, Sunahara H, Tani K, Kobayashi E, Sano M. · Biomedicines. 2025;13(1):234.

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PreclinicalInhaled H₂2025

Preconditioning with hydrogen gas produces cardioprotective effects through autophagy activation in rat cardiomyocytes

Yamada T, Kimura A, Juri T, Suehiro K, Mori T. · BMC pharmacology & toxicology. 2025;26(1):202.

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PreclinicalOther forms2025

Protective Effects of Hydrogen-Rich Saline Against Hemorrhagic Shock in Rats via an Endothelial Glycocalyx Pathway

Kimura A, Suehiro K, Yamada T, Shinta Y, Juri T, Fujimoto Y, Hirano S, Mori T. · Biomedicines. 2025;13(4):833.

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HumanInhaled H₂2024

Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial

Tamura T, Narumiya H, Homma K, Suzuki M, Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care (HYBRID II) Study Group. · Critical care medicine. 2024;52(10):1567-1576.

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HumanInhaled H₂2024

Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China

Ji H, Sun H, Zhang Y, Zhao Z, Gao X, Wang C, Yang Y, Zhang X, Gao J, Man D, Yang Q, Yang Y, Yue C, Chen C, Ding X, Ni T. · Frontiers in cardiovascular medicine. 2024;11:1391282.

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PreclinicalInhaled H₂2024

Hydrogen gas inhalation therapy may not work sufficiently to mitigate oxidative stress induced with REBOA

Matsumura Y, Hayashi Y, Aoki M, Izawa Y. · Scientific reports. 2024;14(1):32128.

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PreclinicalInhaled H₂2024

Hydrogen Gas Inhalation Treatment for Coronary Artery Lesions in a Kawasaki Disease Mouse Model

Shih WL, Yeh TM, Chen KD, Leu S, Liu SF, Huang YH, Kuo HC. · Life (Basel, Switzerland). 2024;14(7):796.

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PreclinicalInhaled H₂2024

Molecular hydrogen attenuates sepsis-induced cardiomyopathy in mice by promoting autophagy

Cui Y, Li Y, Meng S, Song Y, Xie K. · BMC anesthesiology. 2024;24(1):72.

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PreclinicalInhaled H₂2024

Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice

Guo Y, Qin J, Sun R, Hao P, Jiang Z, Wang Y, Gao Z, Zhang H, Xie K, Zhang W. · Biological research. 2024;57(1):43.

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HumanOther forms2024

Molecular Hydrogen Therapy in Sjögren’s Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell

Lin YT, Lu JW, Wu CH, Ho YJ, Lui SW, Hsieh TY, Liu FC. · In vivo (Athens, Greece). 2024;38(6):3117-3124.

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HumanInhaled H₂2024

Pilot Feasibility and Safety Study of Hydrogen Gas Inhalation in Locally Advanced Head and Neck Cancer Patients

Chitapanarux I, Onchan W, Chakrabandhu S, Muangwong P, Autsavapromporn N, Ariyanon T, Akagi J, Mizoo A. · OncoTargets and therapy. 2024;17:863-870.

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PreclinicalH₂-rich water2024

The effect of hydrogen gas on the oxidative stress response in adipose tissue

Tumurbaatar B, Ogawa S, Nakamura N, Yamada T, Minato T, Mori Y, Saiki T, Matsubara T, Naruse K, Suda H. · Scientific reports. 2024;14(1):21425.

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PreclinicalInhaled H₂2024

The Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension

Atiakshin D, Kostin A, Alekhnovich A, Volodkin A, Ignatyuk M, Klabukov I, Baranovskii D, Buchwalow I, Tiemann M, Artemieva M, Medvedeva N, LeBaron TW, Noda M, Medvedev O. · International journal of molecular sciences. 2024;25(20):11010.

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PreclinicalInhaled H₂2023

Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Rats

Kuropatkina T, Atiakshin D, Sychev F, Artemieva M, Samoilenko T, Gerasimova O, Shishkina V, Gufranov K, Medvedeva N, LeBaron TW, Medvedev O. · Biomedicines. 2023;11(12):3141.

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