Molecular Hydrogen Therapy in Sjögren’s Syndrome With Pulmonary Arterial Hypertension and Right-sided Heart Failure: A Case Report of Improved Immune Markers Including Treg, B Cells and Plasma Cell
Lin YT, Lu JW, Wu CH, Ho YJ, Lui SW, Hsieh TY, Liu FC. · In vivo (Athens, Greece). 2024;38(6):3117-3124.
Study at a glance
Human
One woman with Sjögren’s syndrome, pulmonary arterial hypertension and right-sided heart failure.
One oral H₂-generating capsule per day, initiated in May 2023 as adjunctive therapy. · Each capsule contained 170 mg hydrogen-rich coral calcium and was described as providing approximately 1.7×10²¹ hydrogen molecules. The article gives a theoretical equivalence to 24 cups of water at 1,200 ppb or 0.6 mM per 200 mL; those are not directly administered water doses.
Daily from May 2023 through the reported follow-up.
Article-reported result excerpt (24 words maximum): “Adjuvant therapy with hydrogen capsules resulted in increased CD127 + Treg, decreased anti-Ro antibody, decreased B cell subsets ([Figure 3] and [Figure 4]), and…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Case report
Cardiovascular and circulatory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
One woman with Sjögren’s syndrome, pulmonary arterial hypertension and right-sided heart failure.
Single-patient case report.
Daily from May 2023 through the reported follow-up.
One oral H₂-generating capsule per day, initiated in May 2023 as adjunctive therapy.
an oral H₂-generating preparation — H₂ only unless the full text explicitly reports oxygen co-delivery.
Each capsule contained 170 mg hydrogen-rich coral calcium and was described as providing approximately 1.7×10²¹ hydrogen molecules. The article gives a theoretical equivalence to 24 cups of water at 1,200 ppb or 0.6 mM per 200 mL; those are not directly administered water doses.
No concurrent control; before-and-after observations in one patient receiving other therapies.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “Adjuvant therapy with hydrogen capsules resulted in increased CD127 + Treg, decreased anti-Ro antibody, decreased B cell subsets ([Figure 3] and [Figure 4]), and…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this cardiovascular and circulatory health article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39477378 · DOI: 10.21873/invivo.13797
A free full article is available through PubMed Central.
Official PubMed/PMC full article; record re-audited and corrected 25 August 2026.
25 August 2026
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