Hydrogen inhalation therapy alone may not alleviate intestinal mucosal damage in NOMI without total‐layer necrosis: An experimental swine model study
Tanaka Y, Matsumura Y, Hayashi Y, Aoki M, Izawa Y, Endo K, Mato T. · Acute medicine & surgery. 2025;12(1):e70072.
Study at a glance
Preclinical
Eight 3- to 4-month-old female swine in an experimental non-occlusive mesenteric ischemia model.
The H₂ group inhaled 2% H₂ with 25% O₂ from 30 minutes before the start of local mesenteric epinephrine administration until euthanasia at T=240 minutes. · 2% H₂; FiO₂ initially 25% and subsequently regulated to maintain SpO₂ at 95–100%. Total gas flow was not reported.
From T=−30 minutes to euthanasia at T=240 minutes (270 minutes total).
The article reports no significant reduction in intestinal histological ischemic damage, blood-gas measures or 8-OHdG with 2% H₂ in this small swine model.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Cardiovascular and circulatory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Eight 3- to 4-month-old female swine in an experimental non-occlusive mesenteric ischemia model.
8 swine randomized to control (n=4) or H₂ (n=4).
From T=−30 minutes to euthanasia at T=240 minutes (270 minutes total).
The H₂ group inhaled 2% H₂ with 25% O₂ from 30 minutes before the start of local mesenteric epinephrine administration until euthanasia at T=240 minutes.
Inhaled molecular H₂ at 2% with oxygen adjusted to 25%; not Brown’s gas.
2% H₂; FiO₂ initially 25% and subsequently regulated to maintain SpO₂ at 95–100%. Total gas flow was not reported.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
25% O₂ at examination initiation, then FiO₂ adjusted to maintain SpO₂ at 95–100%; absolute O₂ flow was not reported.
Control swine received 25% O₂ without H₂ under the same NOMI protocol.
Outcomes and reported result
Intestinal histological ischemia grade, blood gases, lactate, electrolytes and plasma 8-OHdG.
The article reports no significant reduction in intestinal histological ischemic damage, blood-gas measures or 8-OHdG with 2% H₂ in this small swine model.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 40626114 · DOI: 10.1002/ams2.70072
A free full article is available through PubMed Central.
Official PubMed/PMC full article; record re-audited and corrected 25 August 2026.
25 August 2026
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