Protective effects of hydrogen rich saline solution in rats with experimental myocardial ischemia reperfusion injury
Köksal Z, Kurtipek Ö, Arslan M, Dursun AD, Yığman Z, Özer A. · Heliyon. 2023;9(12):e22973.
Study at a glance
Preclinical
rats, tissue, tissues used to study cardiovascular and circulatory health.
Full text reports H₂ dissolved in saline. No numeric quantity is inferred beyond the source wording. · The full article describes the H₂ intervention but does not report a numeric H₂ concentration.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “The severity level of interstitial edema was found to be significantly different between the groups (p = 0.003).” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Cardiovascular and circulatory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, tissue, tissues used to study cardiovascular and circulatory health.
Preclinical study; group or assay counts reported in the full text include n=6.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in saline. No numeric quantity is inferred beyond the source wording.
H₂ dissolved in saline — H₂ only unless the full text explicitly reports oxygen co-delivery.
The full article describes the H₂ intervention but does not report a numeric H₂ concentration.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “The severity level of interstitial edema was found to be significantly different between the groups (p = 0.003).” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 38076195 · DOI: 10.1016/j.heliyon.2023.e22973
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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