Effects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats
Kawakami K, Matsuo H, Yamada T, Matsumoto KI, Sasaki D, Nomura M. · Experimental animals. 2022;71(3):347-355.
Study at a glance
Preclinical
rats, rat used to study cardiovascular and circulatory health.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 0.1%. · H₂-related quantities reported in the intervention passages: 0.1%. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “Thereafter, in the HW group, the hydrogen concentration decreased gradually to 0.37 ppm after 5 days.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Cardiovascular and circulatory health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, rat used to study cardiovascular and circulatory health.
Preclinical study; the full text reports 10 rats.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 0.1%.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.1%. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures, neurological or behavioral measures
Article-reported result excerpt (24 words maximum): “Thereafter, in the HW group, the hydrogen concentration decreased gradually to 0.37 ppm after 5 days.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 35264492 · DOI: 10.1538/expanim.21-0187
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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