Molecular Hydrogen Therapy for SLE‐PAH: Case Report on Immune Marker Modulation
Tu TH, Lu JW, Wu CH, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In vivo (Athens, Greece). 2025;39(2):1211-1219.
Study at a glance
Human
One 51-year-old woman with systemic lupus erythematosus-associated pulmonary arterial hypertension and right-sided heart failure after severe sepsis.
Daily oral H₂-generating capsules were added as adjunctive therapy in March 2024; the report does not state a capsule count per day in the case narrative. · Each capsule contained 170 mg hydrogen-rich coral calcium and was described as providing approximately 1.7×10²¹ hydrogen molecules. The article gives a theoretical equivalence to 24 cups of water at 1,200 ppb; that is not a directly administered water concentration.
Daily treatment from March 2024 through the reported follow-up.
The report describes stabilization of symptoms and changes in several immune-cell measures after adjunctive capsule use. A single uncontrolled case receiving other treatments cannot establish that the capsules caused these changes.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Case report
Cardiovascular and circulatory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
One 51-year-old woman with systemic lupus erythematosus-associated pulmonary arterial hypertension and right-sided heart failure after severe sepsis.
Single-patient case report.
Daily treatment from March 2024 through the reported follow-up.
Daily oral H₂-generating capsules were added as adjunctive therapy in March 2024; the report does not state a capsule count per day in the case narrative.
an oral H₂-generating preparation — H₂ only unless the full text explicitly reports oxygen co-delivery.
Each capsule contained 170 mg hydrogen-rich coral calcium and was described as providing approximately 1.7×10²¹ hydrogen molecules. The article gives a theoretical equivalence to 24 cups of water at 1,200 ppb; that is not a directly administered water concentration.
No concurrent control; clinical and immune measures were followed over time in one patient receiving multiple treatments.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
The report describes stabilization of symptoms and changes in several immune-cell measures after adjunctive capsule use. A single uncontrolled case receiving other treatments cannot establish that the capsules caused these changes.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this cardiovascular and circulatory health article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 40010970 · DOI: 10.21873/invivo.13926
A free full article is available through PubMed Central.
Official PubMed/PMC full article; record re-audited and corrected 25 August 2026.
25 August 2026
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