Application of Molecular Hydrogen in Early Heart Failure Development: Modulation of Microcirculation, Metabolism, Oxidative Stress, and Myocardial Status
Deryugina AV, Danilova DA, Polozova AV. · Antioxidants (Basel, Switzerland). 2025;14(12):1418.
Study at a glance
Preclinical
rats, tissue, rat, cells used to study metabolic and lipid health.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 2%, 96%, 21%, 40 min. · H₂-related quantities reported in the intervention passages: 2%, 96%, 21%, 40 min. Values are not combined across different experimental arms.
40 min
Article-reported result excerpt (24 words maximum): “Values for intact animals: M_TP—12.56 ± 0.83 perfusion units; Standard deviation—4.64 ± 0.77 perfusion units; Cv—36.92 ± 5.50%. “*”—statistically significant difference compared to intact…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Metabolic and lipid health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, tissue, rat, cells used to study metabolic and lipid health.
Preclinical study; the full text reports 40 animals, with group/assay counts including n=40, n=10, n=2.
40 min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 2%, 96%, 21%, 40 min.
Inhaled molecular H₂ at 2%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 2%, 96%, 21%, 40 min. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
21% O₂ reported; total flow is absent, so O₂ flow in mL/min cannot be calculated.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “Values for intact animals: M_TP—12.56 ± 0.83 perfusion units; Standard deviation—4.64 ± 0.77 perfusion units; Cv—36.92 ± 5.50%. “*”—statistically significant difference compared to intact…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 41462618 · DOI: 10.3390/antiox14121418
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.