Hydrogen-Rich Saline Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Endothelial Dysfunction by Regulating Autophagy through mTOR/TFEB Signaling Pathway
Fu Z, Zhang Z, Wu X, Zhang J. · BioMed research international. 2020;2020:9121894.
Molecular hydrogen (H2) and Cardiovascular and circulatory health
Browse 74 source-checked cardiovascular and circulatory health records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.
74full-text-checked records
17human studies
57animal and laboratory records
No treatment conclusion is impliedClinical events, vascular function, symptoms and biomarkers are kept distinct. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Hydrogen-rich saline mitigates pressure-overload-induced cardiac hypertrophy and atrial fibrillation in rats via the JAK-STAT signalling pathway
Wang C, Pan Z. · J Int Med Res. 2020;48(8):300060520936415.
Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial
Ishibashi T et al. · PLoS One. 2020;15(5):e0233484.
Pharmacokinetics of a single inhalation of hydrogen gas in pigs
Sano M, Ichihara G, Katsumata Y, Hiraide T, Hirai A, Momoi M, Tamura T, Ohata S, Kobayashi E. · PloS one. 2020;15(6):e0234626.
Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water
Li X, Li L, Liu X, Wu J, Sun X, Li Z, Geng YJ, Liu F, Zhou Y. · Current molecular medicine. 2019;19(4):294-302.
Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial ischemia-reperfusion injury via PINK-mediated autophagy
Yao L et al. · Int J Mol Med. 2019;44(3):1048–1062.
Molecular hydrogen suppresses free-radical-induced cell death by mitigating fatty acid peroxidation and mitochondrial dysfunction
Iuchi K, Nishimaki K, Kamimura N, Ohta S. · Can J Physiol Pharmacol. 2019;97(10):999–1005.
Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing VEGF-α expression
Long P, Yan W, He M, Zhang Q, Wang Z, Li M, Xue J, Chen T, An J, Zhang Z. · BMC ophthalmology. 2019;19(1):112.
Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice
Iketani M, Sekimoto K, Igarashi T, Takahashi M, Komatsu M, Sakane I, Takahashi H, Kawaguchi H, Ohtani-Kaneko R, Ohsawa I. · Scientific reports. 2018;8(1):16822.
Hydrogen Flush After Cold Storage as a New End‐Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury
Tamaki I, Hata K, Okamura Y, Nigmet Y, Hirao H, Kubota T, Inamoto O, Kusakabe J, Goto T, Tajima T, Yoshikawa J, Tanaka H, Tsuruyama T, Tolba RH, Uemoto S. · Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2018;24(11):1589-1602.
Hydrogen molecules (H2) improve perfusion recovery via antioxidant effects in experimental peripheral arterial disease
Fu J et al. · Mol Med Rep. 2018;18(6):5009–5015.
Hydrogen-rich solution attenuates myocardial injury caused by cardiopulmonary bypass in rats via the JAK2/STAT3 signaling pathway
Chen K, Sun Y, Diao Y, Zhang T, Dong W. · Oncology Letters. 2018;16(1):167–178.
Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats
Chi J, Li Z, Hong X, Zhao T, Bie Y, Zhang W, Yang J, Feng Z, Yu Z, Xu Q, Zhao L, Liu W, Gao Y, Yang H, Yang J, Liu J, Yang W. · Frontiers in physiology. 2018;9:1026.
Protective effect of hydrogen-rich saline on pressure overload-induced cardiac hypertrophyin rats: possible role of JAK-STAT signaling
Fan Z, Gao Y, Huang Z, Xue F, Wu S, Yang J, Zhu L, Fu L. · BMC cardiovascular disorders. 2018;18(1):32.
Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats.
Yang J, Wu S, Zhu L, Cai J, Fu L. · Molecular Medicine Reports. 2017;16:6849.
Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in isolated rat hearts: a novel cardioprotective intervention
Zálešák M, Kura B, Graban J, Farkašová V, Slezák J, Ravingerová T. · Can J Physiol Pharmacol. 2017;95(8):888–893.
Pharmacological Postconditioning with Lactic Acid and Hydrogen Rich Saline Alleviates Myocardial Reperfusion Injury in Rats
Zhang G, Gao S, Li X, Zhang L, Tan H, Xu L, Chen Y, Geng Y, Lin Y, Aertker B, Sun Y. · Scientific reports. 2015;5:9858.
Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water.
Zhu WJ, Nakayama M, Mori T, Hao K, Terawaki H, Katoh J, Kabayama S, Ito S. · Medical Gas Research. 2013;3:26.
Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras–ERK1/2–MEK1/2 and Akt pathways
Chen Y, Jiang J, Miao H, Chen X, Sun X, Li Y. · Int J Mol Med. 2013;31(3):597–606.
Protection of oral hydrogen water as an antioxidant on pulmonary hypertension
He B, Zhang Y, Kang B, Xiao J, Xie B, Wang Z. · Molecular biology reports. 2013;40(9):5513-5521.
Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies
Nagatani K, Nawashiro H, Takeuchi S, Tomura S, Otani N, Osada H, Wada K, Katoh H, Tsuzuki N, Mori K. · Medical gas research. 2013;3:13.
A basic study on molecular hydrogen (H_2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H_2 level
Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Kaneko K, Nakao A, Imaoka T. · Medical gas research. 2012;2(1):21.
Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study
Takeuchi S, Wada K, Nagatani K, Osada H, Otani N, Nawashiro H. · Intern Med. 2012;51(11):1309–1313.
Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats
Sun Q, Kawamura T, Masutani K, Peng X, Sun Q, Stolz DB, Pribis JP, Billiar TR, Sun X, Bermudez CA, Toyoda Y, Nakao A. · Cardiovascular Research. 2012;94(1):144-153.