Protection of oral hydrogen water as an antioxidant on pulmonary hypertension
He B, Zhang Y, Kang B, Xiao J, Xie B, Wang Z. · Molecular biology reports. 2013;40(9):5513-5521.
Study at a glance
Preclinical
rats, rat, tissue, tissues used to study cardiovascular and circulatory health.
Full text reports H₂ dissolved in drinking water plus H₂ dissolved in saline plus an oral H₂-generating preparation plus an injected or infused H₂ intervention. Detected intervention quantities or schedules: 99.9 %, 0.9 %, 0.6 mmol/L. · H₂-related quantities reported in the intervention passages: 99.9 %, 0.9 %, 0.6 mmol/L. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “There was no significant difference in mPAP within MCT group, MCT+Oral-H_2 group and MCT+Inj-H_2 group ( P > 0.05)..” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Randomized controlled study
Cardiovascular and circulatory health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, rat, tissue, tissues used to study cardiovascular and circulatory health.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water plus H₂ dissolved in saline plus an oral H₂-generating preparation plus an injected or infused H₂ intervention. Detected intervention quantities or schedules: 99.9 %, 0.9 %, 0.6 mmol/L.
H₂ dissolved in drinking water plus H₂ dissolved in saline plus an oral H₂-generating preparation plus an injected or infused H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 99.9 %, 0.9 %, 0.6 mmol/L. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, cardiovascular measures
Article-reported result excerpt (24 words maximum): “There was no significant difference in mPAP within MCT group, MCT+Oral-H_2 group and MCT+Inj-H_2 group ( P > 0.05)..” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 23955545 · DOI: 10.1007/s11033-013-2653-9
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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