Hydrogen may inhibit collagen-induced platelet aggregation: an ex vivo and in vivo study
Takeuchi S, Wada K, Nagatani K, Osada H, Otani N, Nawashiro H. · Intern Med. 2012;51(11):1309–1313.
Study at a glance
Preclinical
Blood samples from human volunteers and rats exposed to hydrogen gas or hydrogen-rich saline.
Hydrogen inhalation in rats and hydrogen-rich saline or hydrogen exposure in platelet experiments. · Article-specific gas and solution exposures.
Acute laboratory and animal exposures.
The article reports suppressed platelet aggregation after the H₂ exposures in the tested systems.
The human component is ex vivo, not a clinical treatment study; the animal and laboratory findings do not establish patient outcomes.
What kind of evidence is this?
Preclinical
Human ex-vivo and controlled rat study
Cardiovascular and circulatory health
Inhaled H₂
Positive laboratory and preclinical signal.
Ex-vivo and animal platelet-function outcomes.
Methods
Blood samples from human volunteers and rats exposed to hydrogen gas or hydrogen-rich saline.
Human ex-vivo and rat experimental samples; arm counts were checked in the article.
Acute laboratory and animal exposures.
Hydrogen inhalation in rats and hydrogen-rich saline or hydrogen exposure in platelet experiments.
Inhaled H₂ gas and H₂ dissolved in saline.
Article-specific gas and solution exposures.
Reported in the full methods for the rat exposure.
Gas exposure used the article’s reported carrier mixture.
Air or vehicle controls.
Outcomes and reported result
Platelet aggregation and related laboratory measures.
The article reports suppressed platelet aggregation after the H₂ exposures in the tested systems.
The full article methods, intervention, outcomes, positive and null findings, funding and conflict statements were checked.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
The human component is ex vivo, not a clinical treatment study; the animal and laboratory findings do not establish patient outcomes.
The tested samples and rat protocol only.
SYRCLE animal-study tool — preliminary
Some concerns
Laboratory comparators were present, but sampling, allocation and blinded assessment were incompletely reported.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 22687834 · DOI: 10.2169/internalmedicine.51.7161
A free publisher or repository full article was checked.
Publisher or repository full article and bibliographic record; checked 10 August 2026.
10 August 2026
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