Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies
Nagatani K, Nawashiro H, Takeuchi S, Tomura S, Otani N, Osada H, Wada K, Katoh H, Tsuzuki N, Mori K. · Medical gas research. 2013;3:13.
Study at a glance
Human
Human participants studied for cardiovascular and circulatory health. See eligibility criteria in the linked full text.
Full text reports H₂ dissolved in another reported solution plus an injected or infused H₂ intervention. Detected intervention quantities or schedules: 200 ml, 1.6 ppm, 1.0 ppm. · H₂-related quantities reported in the intervention passages: 200 ml, 1.6 ppm, 1.0 ppm. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “Analysis of urine sampling and plain chest X-rays showed no indications of pulmonary or urinary tract infection induced by the administration of the H_2-enriched…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Human
Prospective human study
Cardiovascular and circulatory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for cardiovascular and circulatory health. See eligibility criteria in the linked full text.
Human study; the full text reports 38 patients, with group/assay counts including n=38, n=27, n=11, n=10, n=1.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in another reported solution plus an injected or infused H₂ intervention. Detected intervention quantities or schedules: 200 ml, 1.6 ppm, 1.0 ppm.
H₂ dissolved in another reported solution plus an injected or infused H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 200 ml, 1.6 ppm, 1.0 ppm. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “Analysis of urine sampling and plain chest X-rays showed no indications of pulmonary or urinary tract infection induced by the administration of the H_2-enriched…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies only to the population and protocol reported in this cardiovascular and circulatory health article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 23799921 · DOI: 10.1186/2045-9912-3-13
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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