Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies
Nagatani K, Nawashiro H, Takeuchi S, Tomura S, Otani N, Osada H, Wada K, Katoh H, Tsuzuki N, Mori K. · Medical gas research. 2013;3:13.
What kind of evidence is this?
Human
Prospective human study
Cardiovascular and circulatory health
Other forms
Not reported in this record.
Not reported in this record.
Methods at a glance
Human participants studied for cardiovascular and circulatory health. See eligibility criteria in the linked full text.
Human study; the full text reports 38 patients, with group/assay counts including n=38, n=27, n=11, n=10, n=1.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in another reported solution plus an injected or infused H₂ intervention. Detected intervention quantities or schedules: 200 ml, 1.6 ppm, 1.0 ppm.
H₂ dissolved in another reported solution plus an injected or infused H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 200 ml, 1.6 ppm, 1.0 ppm. Values are not combined across different experimental arms.
Not applicable — no inhaled H₂ intervention was identified in the full article.
No inhaled O₂ co-delivery was identified for this non-inhalation intervention.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “Analysis of urine sampling and plain chest X-rays showed no indications of pulmonary or urinary tract infection induced by the administration of the H_2-enriched…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Human evidence; design, sample size and comparator limit interpretation. No funding statement was identified in the machine-readable full article; absence is not inferred. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies only to the population and protocol reported in this cardiovascular and circulatory health article.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 23799921 · DOI: 10.1186/2045-9912-3-13
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10