Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p
Xue X et al. · ESC Heart Fail. 2023;10(5):3077–3090.
Molecular hydrogen (H2) and Cardiovascular and circulatory health
Browse 74 source-checked cardiovascular and circulatory health records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.
74full-text-checked records
17human studies
57animal and laboratory records
No treatment conclusion is impliedClinical events, vascular function, symptoms and biomarkers are kept distinct. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Hydrogen-Rich Saline—A Novel Neuroprotective Agent in a Mouse Model of Experimental Cerebral Ischemia via the ROS-NLRP3 Inflammasome Signaling Pathway In Vivo and In Vitro
Du Y, Chen L, Qiao H, Zhang L, Yang L, Zhang P, Wang J, Zhang C, Jiang W, Xu R, Zhang X. · Brain sciences. 2023;13(6):939.
Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study
Deryugina AV et al. · Med Gas Res. 2023;13(2):59–66.
Protective effects of hydrogen rich saline solution in rats with experimental myocardial ischemia reperfusion injury
Köksal Z, Kurtipek Ö, Arslan M, Dursun AD, Yığman Z, Özer A. · Heliyon. 2023;9(12):e22973.
Effects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats
Kawakami K, Matsuo H, Yamada T, Matsumoto KI, Sasaki D, Nomura M. · Experimental animals. 2022;71(3):347-355.
Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion
Yamamoto R, Suzuki S, Homma K, Yamaguchi S, Sujino T, Sasaki J. · World journal of gastrointestinal surgery. 2022;14(12):1329-1339.
Hydrogen therapy after resuscitation improves myocardial injury involving inhibition of autophagy in an asphyxial rat model of cardiac arrest
Gong X, Fan X, Yin X, Xu T, Li J, Guo J, Zhao X, Wei S, Yuan Q, Wang J, Han X, Chen Y. · Experimental and therapeutic medicine. 2022;23(6):376.
Influence of oxygen concentration on the neuroprotective effect of hydrogen inhalation in a rat model of cardiac arrest
Wang J, Shen Y, Li J, Chen B, Yin C, Li Y. · Frontiers in neurology. 2022;13:996112.
Pharmacokinetics of hydrogen administered intraperitoneally as hydrogen-rich saline and its effect on ischemic neuronal cell death in the brain in gerbils
Hirano M, Sugai K, Fujisawa M, Kobayashi E, Katsumata Y, Hakamata Y, Sano M. · PloS one. 2022;17(12):e0279410.
The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial
Liu B et al. · Front Pharmacol. 2022;13:1025487.
Acute hydrogen-rich water ingestion stimulates cardiac autonomic activity in healthy females
Botek M, Sládečková B, Krejčí J, Pluháček F, Najmanová E. · Acta Gymnica. 2021;51:e2021.009.
Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass
Danilova DA, Brichkin YD, Medvedev AP, Pichugin VV, Fedorov SA, Taranov EV, Nazarov EI, Ryazanov MV, Bolshukhin GV, Deryugina AV. · Sovremennye Tehnologii v Medicine. 2021;13(1):71–77.
Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia
Zhao C, Guo Y, Wang R, Cheng C, Chen X. · The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. 2021;25(6):517-523.
Hydrogen gas inhalation ameliorates cardiac remodelling and fibrosis by regulating NLRP3 inflammasome in myocardial infarction rats
Nie C, Zou R, Pan S, A R, Gao Y, Yang H, Bai J, Xi S, Wang X, Hong X, Yang W. · Journal of Cellular and Molecular Medicine. 2021;25(18):8997–9010.
Hydrogen gas post-conditioning alleviates cognitive dysfunction and anxiety-like behavior in a rat model of subarachnoid hemorrhage
Song JH, Jia HY, Shao TP, Liu ZB, Zhao YP. · Experimental and therapeutic medicine. 2021;22(4):1121.
Hydrogen-rich saline alleviates early brain injury through regulating of ER stress and autophagy after experimental subarachnoid hemorrhage
Jiang B, Li Y, Dai W, Wu A, Wu H, Mao D. · Acta cirurgica brasileira. 2021;36(8):e360804.
Hydrogen-Rich Water Improves Cognitive Ability and Induces Antioxidative, Antiapoptotic, and Anti-Inflammatory Effects in an Acute Ischemia-Reperfusion Injury Mouse Model
Lee D, Choi JI. · BioMed research international. 2021;2021:9956938.
Prenatal Molecular Hydrogen Administration Ameliorates Several Findings in Nitrofen-Induced Congenital Diaphragmatic Hernia
Miura M, Imai K, Tsuda H, Miki R, Tano S, Ito Y, Hirako-Takamura S, Moriyama Y, Ushida T, Iitani Y, Nakano-Kobayashi T, Toyokuni S, Kajiyama H, Kotani T. · International journal of molecular sciences. 2021;22(17):9500.
The Anti-Inflammatory Effect of Hydrogen Gas Inhalation and Its Influence on Laser-Induced Choroidal Neovascularization in a Mouse Model of Neovascular Age-Related Macular Degeneration
Liang IC, Ko WC, Hsu YJ, Lin YR, Chang YH, Zong XH, Lai PC, Chang DC, Hung CF. · International journal of molecular sciences. 2021;22(21):12049.
Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model
Jeong ES, Bajgai J, You IS, Rahman MH, Fadriquela A, Sharma S, Kwon HU, Lee SY, Kim CS, Lee KJ. · International journal of molecular sciences. 2021;22(24):13313.
Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal Ischemia/Reperfusion Injury in Rats through NF- κ B/NLRP3 Pathway
Yang L, Guo Y, Fan X, Chen Y, Yang B, Liu KX, Liu KX, Zhou J. · Mediators of inflammation. 2020;2020:4359305.
Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress
Kiyoi T, Liu S, Takemasa E, Nakaoka H, Hato N, Mogi M. · PloS one. 2020;15(4):e0227582.
Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension
Sugai K, Tamura T, Sano M, Uemura S, Fujisawa M, Katsumata Y, Endo J, Yoshizawa J, Homma K, Suzuki M, Kobayashi E, Sasaki J, Hakamata Y. · Scientific reports. 2020;10(1):20173.
Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model
Tamura T, Sano M, Matsuoka T, Yoshizawa J, Yamamoto R, Katsumata Y, Endo J, Homma K, Kajimura M, Suzuki M, Kobayashi E, Sasaki J. · Shock (Augusta, Ga.). 2020;54(3):377-385.