Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice
Iketani M, Sekimoto K, Igarashi T, Takahashi M, Komatsu M, Sakane I, Takahashi H, Kawaguchi H, Ohtani-Kaneko R, Ohsawa I. · Scientific reports. 2018;8(1):16822.
Study at a glance
Preclinical
mice, mouse, rabbit, rat used to study cardiovascular and circulatory health.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 0.01 μM, 4%, 0.5 ppm, 400 μM. · H₂-related quantities reported in the intervention passages: 0.01 μM, 4%, 0.5 ppm, 400 μM. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “Monoclonal rat anti-macrophages/monocytes antibody (MOMA-2)-positive macrophages and α-smooth muscle actin (SMA)-positive smooth muscle cells mostly did not stain with the p16^INK4a and p21 antibodies…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Cardiovascular and circulatory health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, mouse, rabbit, rat used to study cardiovascular and circulatory health.
Preclinical study; group or assay counts reported in the full text include n=30, n=6.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 0.01 μM, 4%, 0.5 ppm, 400 μM.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.01 μM, 4%, 0.5 ppm, 400 μM. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures, cardiovascular measures
Article-reported result excerpt (24 words maximum): “Monoclonal rat anti-macrophages/monocytes antibody (MOMA-2)-positive macrophages and α-smooth muscle actin (SMA)-positive smooth muscle cells mostly did not stain with the p16^INK4a and p21 antibodies…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 30429524 · DOI: 10.1038/s41598-018-35239-0
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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