Pharmacological Postconditioning with Lactic Acid and Hydrogen Rich Saline Alleviates Myocardial Reperfusion Injury in Rats
Zhang G, Gao S, Li X, Zhang L, Tan H, Xu L, Chen Y, Geng Y, Lin Y, Aertker B, Sun Y. · Scientific reports. 2015;5:9858.
Study at a glance
Preclinical
rats, rat, tissue, tissues used to study cardiovascular and circulatory health.
Full text reports H₂ dissolved in saline. Detected intervention quantities or schedules: 0.9%, 4 mol/L. · H₂-related quantities reported in the intervention passages: 0.9%, 4 mol/L. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “These data showed that a solution consisting of hydrogen rich saline with lactic acid provides a longer duration during which mPTP is inhibited than…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Randomized controlled study
Cardiovascular and circulatory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, rat, tissue, tissues used to study cardiovascular and circulatory health.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in saline. Detected intervention quantities or schedules: 0.9%, 4 mol/L.
H₂ dissolved in saline — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.9%, 4 mol/L. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “These data showed that a solution consisting of hydrogen rich saline with lactic acid provides a longer duration during which mPTP is inhibited than…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 25928542 · DOI: 10.1038/srep09858
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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