Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass
Danilova DA, Brichkin YD, Medvedev AP, Pichugin VV, Fedorov SA, Taranov EV, Nazarov EI, Ryazanov MV, Bolshukhin GV, Deryugina AV. · Sovremennye Tehnologii v Medicine. 2021;13(1):71–77.
Study at a glance
Human
Adults undergoing cardiac surgery with cardiopulmonary bypass for acquired heart-valve disease.
H₂ was added to the ventilator breathing circuit immediately after tracheal intubation and continued throughout the operation. · 1.5–2.0% H₂ in the ventilator circuit.
From intubation through the end of the operation; exact inhalation time varied with surgery and was not reported as one duration.
Selected within-group lipid-peroxidation measures changed during and after surgery, with a different pattern in the untreated group. Baseline marker values differed substantially and the article did not provide a clear randomized between-group estimate. No clinical outcome, organ injury, adverse-event comparison, recovery time, length of stay or mortality endpoint was reported.
Only 20 patients, unclear group formation, no reported randomization or blinding, important baseline marker differences, multiple within-group comparisons and only biochemical surrogate outcomes. The article reported no financial support and no conflicts of interest.
What kind of evidence is this?
Human
Non-randomized two-group perioperative study
Cardiovascular and circulatory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Adults undergoing cardiac surgery with cardiopulmonary bypass for acquired heart-valve disease.
20 patients: 16 men and 4 women; H₂ group n=11 and comparison group n=9.
From intubation through the end of the operation; exact inhalation time varied with surgery and was not reported as one duration.
H₂ was added to the ventilator breathing circuit immediately after tracheal intubation and continued throughout the operation.
Dilute inhaled molecular H₂ — not Brown's gas; no intentional O₂ co-intervention was described.
1.5–2.0% H₂ in the ventilator circuit.
Not reported — the complete article gives concentration but no total circuit flow, so H₂ mL/min cannot be calculated.
Carrier-gas composition, O₂ percentage and O₂ flow were not reported as intervention details.
Nine operated patients did not receive H₂. The article does not report random allocation or blinding.
Outcomes and reported result
Diene and triene conjugates and Schiff bases in arterial and venous blood at anesthesia induction, before and after cardiopulmonary bypass and on postoperative day one.
Selected within-group lipid-peroxidation measures changed during and after surgery, with a different pattern in the untreated group. Baseline marker values differed substantially and the article did not provide a clear randomized between-group estimate. No clinical outcome, organ injury, adverse-event comparison, recovery time, length of stay or mortality endpoint was reported.
The complete English journal/PMC article, patient groups, all four sampling stages, arterial and venous tables, exposure specification, funding and conflicts were checked; the absence of clinical outcomes and absolute gas flow is explicit.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Only 20 patients, unclear group formation, no reported randomization or blinding, important baseline marker differences, multiple within-group comparisons and only biochemical surrogate outcomes. The article reported no financial support and no conflicts of interest.
Adults undergoing valve surgery with cardiopulmonary bypass under this intraoperative protocol; it does not establish improved clinical recovery or safety.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 34513069 · DOI: 10.17691/stm2021.13.1.09
Free full article on the journal site and PubMed Central.
Modern Technologies in Medicine and PMC full articles plus PubMed metadata; full-text and article-status check completed 8 August 2026.
10 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.