Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study
Deryugina AV et al. · Med Gas Res. 2023;13(2):59–66.
Study at a glance
Human
Adults undergoing elective valve surgery with cardiopulmonary bypass
H₂ added to the ventilator breathing circuit immediately after intubation and throughout surgery · 1.5–2.0% H₂ in the breathing circuit; anesthesia used an air–oxygen mixture reported as 50% O₂.
From tracheal intubation throughout the operation; postoperative measures through day 3
Several red-cell laboratory measures and cardiac-function indicators favored the H₂ group. The study was not designed around mortality or major clinical events.
Small perioperative study with an unresolved 20-versus-24 sample inconsistency, unreported gas flow and mainly laboratory outcomes. One author was an employee of the generator manufacturer; public academic-program support was reported.
What kind of evidence is this?
Human
Randomized perioperative clinical study
Cardiovascular and circulatory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Adults undergoing elective valve surgery with cardiopulmonary bypass
The article is internally inconsistent: it states 20 enrolled but describes 24 randomized, 12 per group
From tracheal intubation throughout the operation; postoperative measures through day 3
H₂ added to the ventilator breathing circuit immediately after intubation and throughout surgery
H₂ added to an anesthesia air–oxygen mixture — not Brown’s gas.
1.5–2.0% H₂ in the breathing circuit; anesthesia used an air–oxygen mixture reported as 50% O₂.
Standard anesthesia without added H₂
Outcomes and reported result
Red-blood-cell aggregation, metabolism and oxidative-stress measures; cardiac contractile-function indicators
Several red-cell laboratory measures and cardiac-function indicators favored the H₂ group. The study was not designed around mortality or major clinical events.
Concentration, methods, results, funding and conflicts checked in the open-access full text; sample-size inconsistency and absent flow remain unresolved.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Small perioperative study with an unresolved 20-versus-24 sample inconsistency, unreported gas flow and mainly laboratory outcomes. One author was an employee of the generator manufacturer; public academic-program support was reported.
Adults undergoing elective valve surgery with cardiopulmonary bypass under the reported anesthesia protocol.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36204784 · DOI: 10.4103/2045-9912.356473
Open-access full text is available through PMC.
Open-access PMC full text and PubMed bibliographic record.
10 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.