A double-blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic sudden sensorineural hearing loss
Okada M, Ogawa H, Takagi T, Nishihara E, Yoshida T, Hyodo J, Shinomori Y, Honda N, Fujiwara T, Teraoka M, Yamada H, Hirano SI, Hato N. · Frontiers in neuroscience. 2022;16:1024634.
Study at a glance
Human
Human participants studied for other neurological conditions. See eligibility criteria in the linked full text.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 6 days, 1 month, 3%. · H₂-related quantities reported in the intervention passages: 6 days, 1 month, 3%. Values are not combined across different experimental arms.
6 days
Article-reported result excerpt (24 words maximum): “Furthermore, the ratio of good hearing prognosis (complete and partial recoveries) 3 months after treatment was 64.5% ( n = 20) and 58.8% (…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Randomized controlled study
Other neurological conditions
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for other neurological conditions. See eligibility criteria in the linked full text.
Human study; group or assay counts reported in the full text include n=3, n=4, n=1, n=6, n=31, n=34.
6 days
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 6 days, 1 month, 3%.
Inhaled molecular H₂; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 6 days, 1 month, 3%. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Placebo or matched control reported in the full article.
Outcomes and reported result
clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, cardiovascular measures, respiratory measures
Article-reported result excerpt (24 words maximum): “Furthermore, the ratio of good hearing prognosis (complete and partial recoveries) 3 months after treatment was 64.5% ( n = 20) and 58.8% (…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this other neurological conditions article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36507329 · DOI: 10.3389/fnins.2022.1024634
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
29 September 2026
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