Hydrogen inhalation is associated with a transient rightward shift in prefrontal oxyhemoglobin asymmetry and autonomic modulation
Moriya M, Oyama K, Den Y, Yamada Y, Sakatani K. · Scientific reports. 2026;16(1):6202.
What kind of evidence is this?
Human
Human interventional or observational study
Exercise and recovery
Inhaled H₂
Not reported in this record.
Not reported in this record.
Methods at a glance
Human participants studied for exercise and recovery. See eligibility criteria in the linked full text.
Human study; group or assay counts reported in the full text include n=11, n=9.
300 mL/min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 99.9%, 300 mL/min, 3 min, 15 min, 30 min, 60 min, 90 min, 120 min, 0 min, 40 min.
Inhaled molecular H₂ at 99.9%; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 99.9%, 300 mL/min, 3 min, 15 min, 30 min, 60 min, 90 min, 120 min, 0 min, 40 min. Values are not combined across different experimental arms.
299.7 mL/min H₂, calculated from 99.9% H₂ and 300 mL/min total flow reported in the full text.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, neurological or behavioral measures, cardiovascular measures
Article-reported result excerpt (24 words maximum): “These results demonstrate that hydrogen inhalation is associated with a transient rightward shift in oxy-Hb hemispheric asymmetry, most evident during and immediately after the…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this exercise and recovery article.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 41582106 · DOI: 10.1038/s41598-026-36599-8
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10