Administration route

Inhaled molecular hydrogen research

Inhaled molecular hydrogen research: 185 source-checked studies (63 human; 122 preclinical). Compare delivery, outcomes and limitations.

185all study records 63human studies 122animal and laboratory records

Choose an evidence group to browse its records. Start with the molecular hydrogen research overview.

No treatment conclusion is impliedH₂ concentration, gas mixture, delivery system, flow, duration and treatment schedules vary and must not be treated as interchangeable. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.

PreclinicalInhaled H₂2025

Hydrogen inhalation therapy alone may not alleviate intestinal mucosal damage in NOMI without total‐layer necrosis: An experimental swine model study

Tanaka Y, Matsumura Y, Hayashi Y, Aoki M, Izawa Y, Endo K, Mato T. · Acute medicine & surgery. 2025;12(1):e70072.

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HumanInhaled H₂2025

Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis

Wang C et al. · Front Pharmacol. 2025;16:1505922.

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PreclinicalInhaled H₂2025

Molecular Hydrogen Affords Similar Neuroprotection to Therapeutic Hypothermia in a Porcine Model of Neonatal Hypoxic–Ischemic Encephalopathy

Balog E, Remzső G, Tóth-Szűki V, Rózsa É, Kovács V, Domoki F. · Antioxidants (Basel, Switzerland). 2025;14(12):1405.

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PreclinicalInhaled H₂2025

Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption

Pascal-Moussellard V, Alcaraz JP, Tanguy S, Salomez-Ihl C, Cinquin P, Boucher F, Boucher E. · Scientific reports. 2025;15(1):11482.

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PreclinicalInhaled H₂2025

Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism

Tian Y, Su H, Chen Y, Geng X, Zhang Y, Wang Y, Tang W, Fan W, Zhou J, Wei Y. · Molecular biology reports. 2025;52(1):751.

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HumanInhaled H₂2025

Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study

Grepl P et al. · Med Gas Res. 2025;15(3):367–373.

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PreclinicalInhaled H₂2025

Molecular hydrogen mitigates traumatic brain injury-induced lung injury via NLRP3 inflammasome inhibition

Liu L, Wang S, Jiang L, Wang J, Chen J, Zhang H, Wang Y. · BMC chemistry. 2025;19(1):138.

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PreclinicalInhaled H₂2025

Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch through a SIRT1–β-catenin pathway in mice

Zhang L et al. · Redox Biol. 2025;79:103472.

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PreclinicalInhaled H₂2025

Preconditioning with hydrogen gas produces cardioprotective effects through autophagy activation in rat cardiomyocytes

Yamada T, Kimura A, Juri T, Suehiro K, Mori T. · BMC pharmacology & toxicology. 2025;26(1):202.

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HumanInhaled H₂2025

The Improvement of Physical Function and Caregiver Burden by a Multimodal Intervention: A Case Study of Combined Exercise Therapy, Nutritional Guidance, and Hydrogen Gas Inhalation Therapy

Harada Y, Okamura R, Sawano J, Koide N, Miyakawa M. · Cureus. 2025;17(2):e79516.

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PreclinicalInhaled H₂2024

Additive effect of clove essential oil combined with hydrogen inhalation improves psychological harm caused by lipopolysaccharide in mice

Sung WW, Yeh TM, Shih WL. · BMC complementary medicine and therapies. 2024;24(1):399.

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HumanInhaled H₂2024

Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial

Tamura T, Narumiya H, Homma K, Suzuki M, Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care (HYBRID II) Study Group. · Critical care medicine. 2024;52(10):1567-1576.

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PreclinicalInhaled H₂2024

Effect of hydrogen inhalation on cardiovascular and interstitial components of pulmonary hypertension in rats

Kuropatkina TA, Gufranov K, Sychev FY, et al. · Pulmonologiya. 2024;34(1):19–30.

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HumanInhaled H₂2024

Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China

Ji H, Sun H, Zhang Y, Zhao Z, Gao X, Wang C, Yang Y, Zhang X, Gao J, Man D, Yang Q, Yang Y, Yue C, Chen C, Ding X, Ni T. · Frontiers in cardiovascular medicine. 2024;11:1391282.

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HumanInhaled H₂2024

Effects of perioperative hydrogen inhalation on brain edema and prognosis in patients with glioma: a single-center, randomized controlled study

Wu F et al. · Front Neurol. 2024;15:1413904.

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HumanInhaled H₂2024

H₂ inhalation therapy in patients with moderate COVID-19 (H2COVID): a prospective ascending-dose phase I clinical trial

Salomez-Ihl C, Giai J, Barbado M, Paris A, Touati S, Alcaraz JP, Tanguy S, Leroy C, Lehmann A, Degano B, Gavard M, Bedouch P, Pavese P, Moreau-Gaudry A, Roustit M, Boucher F, Cinquin P, Brion JP. · Antimicrob Agents Chemother. 2024;68(8):e0057324.

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PreclinicalInhaled H₂2024

High‐concentration hydrogen inhalation mitigates sepsis‐associated encephalopathy in mice by improving mitochondrial dynamics

Cui Y, Meng S, Zhang N, Liu J, Zheng L, Ma W, Song Y, Wang Z, Shen Y, Liu J, Xie K. · CNS neuroscience & therapeutics. 2024;30(9):e70021.

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PreclinicalInhaled H₂2024

Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model

He W, Rahman MH, Bajgai J, Abdul-Nasir S, Mo C, Ma H, Goh SH, Bomi K, Jung H, Kim CS, Lee H, Lee KJ. · Antioxidants (Basel, Switzerland). 2024;13(11):1328.

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PreclinicalInhaled H₂2024

Hydrogen gas inhalation ameliorates LPS-induced BPD by inhibiting inflammation via regulating the TLR4–NFκB–IL6/NLRP3 signaling pathway in the placenta

Zhang Y, Ren X, Zhang L, Sun X, Li W, Chen Y, Tian Y, Chu Z, Wei Y, Yao G, Wang Y. · European journal of medical research. 2024;29(1):285.

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HumanInhaled H₂2024

Hydrogen gas inhalation prior to high-intensity training reduces attenuation of nitric oxide bioavailability in male rugby players

Zhao Y, Li C, Zhou S, Xu Z, Huang X, Wen L. · PeerJ. 2024;12:e18503.

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PreclinicalInhaled H₂2024

Hydrogen gas inhalation therapy may not work sufficiently to mitigate oxidative stress induced with REBOA

Matsumura Y, Hayashi Y, Aoki M, Izawa Y. · Scientific reports. 2024;14(1):32128.

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PreclinicalInhaled H₂2024

Hydrogen Gas Inhalation Treatment for Coronary Artery Lesions in a Kawasaki Disease Mouse Model

Shih WL, Yeh TM, Chen KD, Leu S, Liu SF, Huang YH, Kuo HC. · Life (Basel, Switzerland). 2024;14(7):796.

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HumanInhaled H₂2024

Hydrogen inhalation: A novel approach to alleviating allergic rhinitis symptoms by modulating nasal flora^[☆]

Wang N, Ma Q, Zhai J, Che Y, Liu J, Tang T, Sun Y, Wang J, Yang W. · The World Allergy Organization journal. 2024;17(10):100970.

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PreclinicalInhaled H₂2024

Hydrogen therapy promotes macrophage polarization to the M2 subtype in radiation lung injury by inhibiting the NF-κB signalling pathway

Gao X, Niu S, Li L, Zhang X, Cao X, Zhang X, Pan W, Sun M, Zhao G, Zheng X, Song G, Zhang Y. · Heliyon. 2024;10(10):e30902.

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