Effect of hydrogen inhalation on functional characteristics and intestinal gas biomarkers in wrestlers during physical exercise
Medvedev OS, Uzhakov AA, Konnova OL, Povarova OV. · Sports Medicine: Research and Practice. 2025;15(2):20–30.
What kind of evidence is this?
Human
Prospective uncontrolled before-and-after pilot study
Exercise and recovery
Inhaled H₂
Not reported in this record.
Not reported in this record.
Methods at a glance
Healthy male mixed-martial-arts athletes.
10 men; median age 20 years. Median number of hydrogen sessions was 33 (interquartile range 29–47).
30–120 minutes per session for about one month; median 33 sessions.
Nasal-cannula inhalation from an MN-H0900 generator; sessions varied from 30 to 120 minutes over approximately one month.
Brown's gas / oxyhydrogen — H₂ and O₂ co-delivered, not H₂ alone.
The article reports 600 mL H₂ and 300 mL O₂, described as 66% H₂ and 34% O₂. Context indicates generator output rates, although the unit '/min' is omitted in that sentence.
600 mL/min H₂ is the apparent device-output rate; the article prints '600 mL hydrogen' without explicitly adding '/min', so this unit interpretation remains flagged.
300 mL/min O₂ is the apparent co-delivered device-output rate; the article describes the mixture as 34% O₂.
Participants' own pre-intervention measurements; no sham or parallel control.
Outcomes and reported result
Exhaled H₂/CH₄, blood count, biochemistry, coagulation, treadmill and rowing tests, lactate and cardiovascular recovery.
Several pre/post measures changed, including lower alkaline phosphatase, lower pre-exercise lactate, higher post-exercise lactate, longer APTT and greater 2-minute rowing distance. Complete blood count did not change.
The complete free bilingual publisher full article, methods, tables, positive and null findings were checked.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Only 10 participants, no control or sham, variable exposure and many outcomes. The article omits '/min' beside the printed 600 mL H₂ and 300 mL O₂ values; Hydrogenology flags the flow-unit interpretation instead of presenting it as certain.
Young male combat-sport athletes in an uncontrolled one-month pilot.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
OpenAlex ID: W4416319759 · DOI: 10.47529/2223-2524.2025.2.4
Open-access publisher article.
Sports Medicine: Research and Practice full article; full-text extraction checked 8 August 2026.
2026-08-10