Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
Liu B, Bao Y, Ma J, Wang X, Feng Y. · Advances in radiation oncology. 2025;10(11):101879.
What kind of evidence is this?
Human
Prospective human study
Cancer research
Inhaled H₂
Not reported in this record.
Not reported in this record.
Methods at a glance
Human participants studied for cancer research. See eligibility criteria in the linked full text.
Human study; the full text reports 66 patients, with group/assay counts including n=28, n=30.
2 hours
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 66.6%, 33.3%, 2 hours, 3 L/min.
Brown’s gas / oxyhydrogen — H₂ and O₂ co-delivered, not H₂ alone.
H₂-related quantities reported in the intervention passages: 66.6%, 33.3%, 2 hours, 3 L/min. Values are not combined across different experimental arms.
1998 mL/min H₂, calculated from 66.6% H₂ and 3000 mL/min total flow reported in the full text.
33.3% O₂; 999 mL/min O₂ calculated from the reported total flow.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “The overall trend analysis confirmed a significant group effect ( P < .0001), demonstrating that hydrogen inhalation suppressed radiation-induced upregulation of IL-6 levels and…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Human evidence; design, sample size and comparator limit interpretation. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies only to the population and protocol reported in this cancer research article.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 41020280 · DOI: 10.1016/j.adro.2025.101879
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10