Electrolyzed Hydrogen Water Improves Chemosensitivity to Anticancer Drugs by Potently Suppressing Autophagy
Yano S, Xie L, Li J, Sugaya Y, Miyauchi Y, Kabayama S, Hara T. · Journal of cellular and molecular medicine. 2026;30(4):e71011.
Molecular hydrogen (H2) and Cancer research
Browse 43 source-checked cancer research records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.
43full-text-checked records
11human studies
32animal and laboratory records
No treatment conclusion is impliedCancer type, treatment setting and evidence stream matter; case reports and models are not clinical proof. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice
Hori F et al. · Int J Mol Sci. 2026;27(2):635.
Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
Liu B, Bao Y, Ma J, Wang X, Feng Y. · Advances in radiation oncology. 2025;10(11):101879.
Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial
Maruyama T, Takayama E, Tokuno S, Morita M, Ekuni D. · Healthcare (Basel, Switzerland). 2025;13(5):577.
Four-dimensional data independent acquisition proteomics and metabolomics reveal mechanisms of hydrogen-rich water at Zusanli (ST36) point against triple-negative breast cancer in mice
Liu J, Mo Q, Lei G, Jia Y, Li A, Jia C, Pan L. · Journal of Traditional Chinese Medicine. 2025.
Hydrogen-Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine-125 Brachytherapy.
Hu P, Lin L, Chen G, Liu D, Guo H, Xiao M, Zhong Z, Yang G, Xu B, Huang D, Peng S, Li Y, Zhang Y, Huang T, Zhang F. · Advanced Science. 2025;12:2412263.
Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption
Pascal-Moussellard V, Alcaraz JP, Tanguy S, Salomez-Ihl C, Cinquin P, Boucher F, Boucher E. · Scientific reports. 2025;15(1):11482.
Preventing Cisplatin-Induced Neuropathy and Related Emotional Disorders with the Coadministration of Duloxetine and Hydrogen-Rich Water in Male and Female Mice
Martínez-Martel I, Negrini-Ferrari SE, Pol O. · Antioxidants (Basel, Switzerland). 2025;14(8):1004.
Radio-protective effects of ultra-fine bubble hydrogen water and serum protein responses in whole-body radiation-exposed mice
Yamaguchi M, Htun KT, Tatara Y, Sato Y, Hosoda M, Kothan S, Kamimura C, Inanami O, Kashiwakura I. · Scientific reports. 2025;15(1):4447.
Research on the inhibitory effect of hydrogen gas on ovarian cancer and potential mechanisms
Yin M, Liu M, Zhang C, Peng L, Guo Z, Hao Y, Wang Y, Zhang X, Shi Q, Ren X, Li H, Zhang L. · European journal of medical research. 2025;30(1):874.
Hydrogen Therapy Reverses Cancer‐Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti‐Tumor Immunity
Meng X, Liu Z, Deng L, Yang Y, Zhu Y, Sun X, Hao Y, He Y, Fu J. · Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024;11(28):e2401269.
The Combination of Molecular Hydrogen and Heme Oxygenase 1 Effectively Inhibits Neuropathy Caused by Paclitaxel in Mice
Martínez-Martel I, Bai X, Kordikowski R, Leite-Panissi CRA, Pol O. · Antioxidants (Basel, Switzerland). 2024;13(7):856.
Effects of hydrogen-rich water on hamsters with experimental myeloid tumor
Toshkova R, Neshev N, Ignatov I, Huether F, Ignatov AI, Angushev I. · Libri Oncologici. 2023;51(2-3):85–96.
Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis
Zan R, Wang H, Cai W, Ni J, Luthringer-Feyerabend BJC, Wang W, Peng H, Ji W, Yan J, Xia J, Song Y, Zhang X. · 2022.
Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
Asgharzadeh F, Tarnava A, Mostafapour A, Khazaei M, LeBaron TW. · World journal of gastrointestinal oncology. 2022;14(1):242-252.
Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway
Zhang X et al. · Biomed Res Int. 2022;2022:8024452.
Hydrogen-Generating Silica Material Prevents UVA-Ray-Induced Cellular Oxidative Stress, Cell Death, Collagen Loss and Melanogenesis in Human Cells and 3D Skin Equivalents
Xiao L, Mochizuki M, Nakahara T, Miwa N. · Antioxidants (Basel, Switzerland). 2021;10(1):76.
Protective effects of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study
Hirano SI, Aoki Y, Li XK, Ichimaru N, Takahara S, Takefuji Y. · Medical Gas Research. 2021;11(3):104–109.
Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
Akagi J, Baba H. · Oncology Letters. 2020;20(5):258.
Hydrogen gas represses the progression of lung cancer via down-regulating CD47
Meng J, Liu L, Wang D, Yan Z, Chen G. · Bioscience Reports. 2020;40(4):BSR20192761.
Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
Yang Y, Liu PY, Bao W, Chen SJ, Wu FS, Zhu PY. · 2020.
Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of medications in patients with advanced non-small cell lung cancer.
Chen JB, Kong XF, Mu F, Lu TY, Lu YY, Xu KC. · Medical Gas Research. 2020;10:285560.
RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via TNF and NF-κB pathways
Yang Y, Liu YP, Bao W, Chen JS, Xi XW. · Translational cancer research. 2020;9(5):3468-3482.
Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study
Chen JB et al. · Med Gas Res. 2020;10(4):149–154.