Pilot Feasibility and Safety Study of Hydrogen Gas Inhalation in Locally Advanced Head and Neck Cancer Patients
Chitapanarux I, Onchan W, Chakrabandhu S, Muangwong P, Autsavapromporn N, Ariyanon T, Akagi J, Mizoo A. · OncoTargets and therapy. 2024;17:863-870.
Study at a glance
Human
Human participants studied for cardiovascular and circulatory health. See eligibility criteria in the linked full text.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 1 hour, 2 hours, 80%, 99.99%, 66%, 1.2 L/min. · H₂-related quantities reported in the intervention passages: 1 hour, 2 hours, 80%, 99.99%, 66%, 1.2 L/min. Values are not combined across different experimental arms.
1 hour
Article-reported result excerpt (24 words maximum): “Regarding the safety of H_2 gas inhalation, we did not find any adverse events or symptoms related to H_2 gas, including cough, epistaxis, headache,…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Human interventional or observational study
Cardiovascular and circulatory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for cardiovascular and circulatory health. See eligibility criteria in the linked full text.
Human study; the full text reports 10 patients.
1 hour
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 1 hour, 2 hours, 80%, 99.99%, 66%, 1.2 L/min.
Inhaled molecular H₂ at 99.99%; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 1 hour, 2 hours, 80%, 99.99%, 66%, 1.2 L/min. Values are not combined across different experimental arms.
1199.88 mL/min H₂, calculated from 99.99% H₂ and 1200 mL/min total flow reported in the full text.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “Regarding the safety of H_2 gas inhalation, we did not find any adverse events or symptoms related to H_2 gas, including cough, epistaxis, headache,…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this cardiovascular and circulatory health article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39493677 · DOI: 10.2147/ott.s478613
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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