Immunomodulatory Effects of Molecular Hydrogen Therapy in Systemic Lupus Erythematosus With Pericarditis and Pleuritis: A Case Report
Tu TH, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In vivo (Athens, Greece). 2025;39(5):3014-3024.
Molecular hydrogen (H2) and Immune and inflammatory conditions
Browse 24 source-checked immune and inflammatory conditions records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.
24full-text-checked records
11human studies
13animal and laboratory records
No treatment conclusion is impliedA biomarker change is not automatically a clinical effect, and evidence streams remain separate. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Hydrogen treatment reduces electroencephalographic activity and neuronal death in rats with refractory status epilepticus by inhibiting membrane NR2B phosphorylation and oxidative stress
Jia R, Zhu G, Zhao R, Li T, Jiang W, Cui X. · The Journal of international medical research. 2024;52(3):3000605241235589.
Assessment of the effects of hydrogen water on human gingival fibroblast cell culture in patients with chronic periodontitis
Bhatt A, Nayak A, Bhat K, Bogar C, Nayak R, Naik S. · Journal of Indian Society of Periodontology. 2023;27(3):278-282.
Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study
Videhult Pierre P, Fransson A, Kisiel MA, Laurell G. · The Annals of otology, rhinology, and laryngology. 2023;132(8):865-872.
Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum
Tanaka Y, Xiao L, Miwa N. · Medical Gas Research. 2022;12(3):91–99.
The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, Double-Blind Clinical Trial
Jin L, Fan K, Tan S, Liu S, Ge Q, Wang Y, Ai Z, Yu S. · Journal of inflammation research. 2022;15:3983-3995.
Effect of hydrogen gas inhalation on T lymphocyte subsets in infectious mononucleosis
Liu H, Song S, Li J, Liu S, Yan J, Yan J, Li L, Li N, Wang P, Yin X, Wei Y, Lin A. · Adv Clin Med. 2021;11(10):4424–4430.
High-flow hydrogen inhalation might suppresses the immune function of middle-aged participants: a self-controlled study
Chen JB, Kong XF, Mu F. · Medical Gas Research. 2021;11(1):12–17.
Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial
Qian L, Liu M, Shen J, Cen J, Zhao D. · Frontiers in Immunology. 2020;11:598359.
Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial
Sim M et al. · Sci Rep. 2020;10(1):12130.
Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis
Fang S, Li X, Wei X, Zhang Y, Ma Z, Wei Y, Wang W. · Experimental and therapeutic medicine. 2018;16(6):5178-5184.
Effect of Hydrogen-Rich Saline on Postoperative Intra-Abdominal Adhesion Bands Formation in Mice
Liu Z, Cheng S, Gu C, Pei H, Hong X. · Medical science monitor : international medical journal of experimental and clinical research. 2017;23:5363-5373.
Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress
Yu S, Zhao C, Che N, Jing L, Ge R. · Journal of inflammation (London, England). 2017;14:1.
Therapeutic effects of hydrogen on chronic graft-versus-host disease
Qian L, Liu X, Shen J, Zhao D, Yin W. · Journal of Cellular and Molecular Medicine. 2017;21(10):2627–2630.
Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators
Iuchi K, Imoto A, Kamimura N, Nishimaki K, Ichimiya H, Yokota T, Ohta S. · Scientific reports. 2016;6:18971.
New Approach in Translational Medicine: Effects of Electrolyzed Reduced Water (ERW) on NF-κB/iNOS Pathway in U937 Cell Line under Altered Redox State
Franceschelli S, Gatta DM, Pesce M, Ferrone A, Patruno A, de Lutiis MA, Grilli A, Felaco M, Croce F, Speranza L. · International journal of molecular sciences. 2016;17(9):E1461.
Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis
Zhou HX, Han B, Hou LM, An TT, Jia G, Cheng ZX, Ma Y, Zhou YN, Kong R, Wang SJ, Wang YW, Sun XJ, Pan SH, Sun B. · PloS one. 2016;11(4):e0154483.
Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease
Qian LR, Shen JL. · Medical Gas Research. 2016;6(3):177–179.
Hydrogen-Rich Saline Inhibits NLRP3 Inflammasome Activation and Attenuates Experimental Acute Pancreatitis in Mice
Ren JD, Ma J, Hou J, Xiao WJ, Jin WH, Wu J, Fan KH. · Mediators of inflammation. 2014;2014:930894.
Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction
Zhao S, Yang Y, Liu W, Xuan Z, Wu S, Yu S, Mei K, Huang Y, Zhang P, Cai J, Ni J, Zhao Y. · Journal of cellular and molecular medicine. 2014;18(5):938-946.
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study
Ishibashi T et al. · Int Immunopharmacol. 2014;21(2):468–473.
Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study
Ishibashi T et al. · Med Gas Res. 2012;2(1):27.
Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis
Yang Y, Li B, Liu C, Chuai Y, Lei J, Gao F, Cui J, Sun D, Cheng Y, Zhou C, Cai J. · Medical science monitor : international medical journal of experimental and clinical research. 2012;18(4):BR144-8.
Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice
Spulber S et al. · PLoS One. 2012;7(7):e42078.