Biomarkers are not symptoms
A cytokine or oxidative-stress change does not automatically mean that a person feels or functions better.
Browse 24 source-checked immune and inflammatory conditions records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.
This collection contains 24 source-checked records: 11 human studies and 13 animal or laboratory records. Immune pathways, cytokines, oxidative-stress measures, symptoms and clinical disease activity are different outcome classes.
A cytokine or oxidative-stress change does not automatically mean that a person feels or functions better.
Findings from one inflammatory or immune-mediated condition should not be generalized to another without direct evidence.
Acute experimental inflammation and chronic human disease differ in duration, biology and treatment context.
Tu TH, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In vivo (Athens, Greece). 2025;39(5):3014-3024.
Jia R, Zhu G, Zhao R, Li T, Jiang W, Cui X. · The Journal of international medical research. 2024;52(3):3000605241235589.
Bhatt A, Nayak A, Bhat K, Bogar C, Nayak R, Naik S. · Journal of Indian Society of Periodontology. 2023;27(3):278-282.
Videhult Pierre P, Fransson A, Kisiel MA, Laurell G. · The Annals of otology, rhinology, and laryngology. 2023;132(8):865-872.
Tanaka Y, Xiao L, Miwa N. · Medical Gas Research. 2022;12(3):91–99.
Jin L, Fan K, Tan S, Liu S, Ge Q, Wang Y, Ai Z, Yu S. · Journal of inflammation research. 2022;15:3983-3995.
Liu H, Song S, Li J, Liu S, Yan J, Yan J, Li L, Li N, Wang P, Yin X, Wei Y, Lin A. · Adv Clin Med. 2021;11(10):4424–4430.
Chen JB, Kong XF, Mu F. · Medical Gas Research. 2021;11(1):12–17.
Qian L, Liu M, Shen J, Cen J, Zhao D. · Frontiers in Immunology. 2020;11:598359.
Sim M et al. · Sci Rep. 2020;10(1):12130.
Fang S, Li X, Wei X, Zhang Y, Ma Z, Wei Y, Wang W. · Experimental and therapeutic medicine. 2018;16(6):5178-5184.
Liu Z, Cheng S, Gu C, Pei H, Hong X. · Medical science monitor : international medical journal of experimental and clinical research. 2017;23:5363-5373.
Yu S, Zhao C, Che N, Jing L, Ge R. · Journal of inflammation (London, England). 2017;14:1.
Qian L, Liu X, Shen J, Zhao D, Yin W. · Journal of Cellular and Molecular Medicine. 2017;21(10):2627–2630.
Iuchi K, Imoto A, Kamimura N, Nishimaki K, Ichimiya H, Yokota T, Ohta S. · Scientific reports. 2016;6:18971.
Franceschelli S, Gatta DM, Pesce M, Ferrone A, Patruno A, de Lutiis MA, Grilli A, Felaco M, Croce F, Speranza L. · International journal of molecular sciences. 2016;17(9):E1461.
Zhou HX, Han B, Hou LM, An TT, Jia G, Cheng ZX, Ma Y, Zhou YN, Kong R, Wang SJ, Wang YW, Sun XJ, Pan SH, Sun B. · PloS one. 2016;11(4):e0154483.
Qian LR, Shen JL. · Medical Gas Research. 2016;6(3):177–179.
Ren JD, Ma J, Hou J, Xiao WJ, Jin WH, Wu J, Fan KH. · Mediators of inflammation. 2014;2014:930894.
Zhao S, Yang Y, Liu W, Xuan Z, Wu S, Yu S, Mei K, Huang Y, Zhang P, Cai J, Ni J, Zhao Y. · Journal of cellular and molecular medicine. 2014;18(5):938-946.
Ishibashi T et al. · Int Immunopharmacol. 2014;21(2):468–473.
Ishibashi T et al. · Med Gas Res. 2012;2(1):27.
Yang Y, Li B, Liu C, Chuai Y, Lei J, Gao F, Cui J, Sun D, Cheng Y, Zhou C, Cai J. · Medical science monitor : international medical journal of experimental and clinical research. 2012;18(4):BR144-8.
Spulber S et al. · PLoS One. 2012;7(7):e42078.