Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial
Maruyama T et al. · Biomedicines. 2025;13(8):1799.
Molecular hydrogen (H2) and Gastrointestinal health
Browse 19 source-checked gastrointestinal health records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.
19full-text-checked records
3human studies
16animal and laboratory records
No treatment conclusion is impliedSymptoms, disease activity, function and microbiome-related measures are not treated as equivalent. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
The gastroprotective effect of hydrogen-rich coral calcium in a mouse model of peptic ulcer disease
Wu HT, Hsieh MT, Ou HY, Chao TH, Tsai LM. · Drug Design, Development and Therapy. 2025;19:9845–9851.
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.
McCurry MD, D'Agostino GD, Walsh JT, Bisanz JE, Zalosnik I, Dong X, Morris DJ, Korzenik JR, Edlow AG, Balskus EP, Turnbaugh PJ, Huh JR, Devlin AS. · Cell. 2024;187:2717-2732.
Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway
Chen KD, Wang KL, Chen C, Zhu YJ, Tang WW, Wang YJ, Chen ZP, He LH, Chen YG, Zhang W. · World J Gastroenterol. 2024;30(20):2709–2725.
Ameliorating Role of Hydrogen-Rich Water Against NSAID-Induced Enteropathy via Reduction of ROS and Production of Short-Chain Fatty Acids
Akita Y, Higashiyama M, Kurihara C, Ito S, Nishii S, Mizoguchi A, Inaba K, Tanemoto R, Sugihara N, Hanawa Y, Wada A, Horiuchi K, Okada Y, Narimatsu K, Komoto S, Tomita K, Takei F, Satoh Y, Saruta M, Hokari R. · Digestive diseases and sciences. 2023;68(5):1824-1834.
Hydrogen gas and the gut microbiota are potential biomarkers for the development of experimental colitis in mice
Fujiki Y, Tanaka T, Yakabe K, Seki N, Akiyama M, Uchida K, Kim YG. · Gut Microbiome. 2023;5:e3.
Hydrogen-Rich Water Mitigates LPS-Induced Chronic Intestinal Inflammatory Response in Rats via Nrf-2 and NF-κB Signaling Pathways
Peng J, He Q, Li S, Liu T, Zhang J. · Veterinary sciences. 2022;9(11):621.
Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier
Ge L, Qi J, Shao B, Ruan Z, Ren Y, Sui S, Wu X, Sun X, Liu S, Li S, Xu C, Song W. · 2022.
Molecular hydrogen is comparable to sulfasalazine as a treatment for DSS-induced colitis in mice
LeBaron TW, Asgharzadeh F, Khazei M, Kura B, Tarnava A, Slezak J. · EXCLI journal. 2021;20:1106-1117.
The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and gut microbiota: a double-blind randomized trial.
Tanaka Y, Kiuchi M, Higashimura Y, Naito Y, Koyama K. · Medical Gas Research. 2021;11:318858.
Protective Role of Hydrogen Gas on Oxidative Damage and Apoptosis in Intestinal Porcine Epithelial Cells (IPEC-J2) Induced by Deoxynivalenol: A Preliminary Study
Ji X, Zheng W, Yao W. · Toxins. 2019;12(1):E5.
Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice
Higashimura Y, Baba Y, Inoue R, Takagi T, Uchiyama K, Mizushima K, Hirai Y, Ushiroda C, Tanaka Y, Naito Y. · Medical Gas Research. 2018;8(1):6–11.
Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota
Xiao HW, Li Y, Luo D, Dong JL, Zhou LX, Zhao SY, Zheng QS, Wang HC, Cui M, Fan SJ. · Experimental & Molecular Medicine. 2018;50(1):e433.
Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen
Franceschelli S et al. · J Cell Mol Med. 2018;22(5):2750–2759.
Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression
Shen NY et al. · World J Gastroenterol. 2017;23(8):1375-1386.
Inhaled hydrogen ameliorates endotoxin‐induced bowel dysfunction
Sakata H, Okamoto A, Aoyama-Ishikawa M, Yamashita H, Kohama K, Fujisaki N, Yamada T, Kotani J, Tsukahara K, Iida A, Nakao A. · 2017.
Protective effects of hydrogen rich water on the intestinal ischemia/reperfusion injury due to intestinal intussusception in a rat model
Wu MJ, Chen M, Sang S, Hou LL, Tian ML, Li K, Lv FQ. · Medical Gas Research. 2017;7(2):101–106.
Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water
Xue J, Shang G, Tanaka Y, Saihara Y, Hou L, Velasquez N, Liu W, Lu Y. · 2014.
Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats
Zhang JY, Wu QF, Wan Y, et al. · World Journal of Gastroenterology. 2014;20(6):1614–1622.