Hydrogen gas and preservation of intestinal stem cells in mesenteric ischemia and reperfusion
Yamamoto R, Suzuki S, Homma K, Yamaguchi S, Sujino T, Sasaki J. · World journal of gastrointestinal surgery. 2022;14(12):1329-1339.
Study at a glance
Preclinical
rats, rat, tissues, rabbit used to study cardiovascular and circulatory health.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 3%, 0.2 L/min, 0.3%. · H₂-related quantities reported in the intervention passages: 3%, 0.2 L/min, 0.3%. Values are not combined across different experimental arms.
0.2 L/min
Article-reported result excerpt (24 words maximum): “Olfactomedin 4 expression was also relatively higher in the hydrogen group than in the reperfusion group, although the differences were not significant; B: Hes1…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Cardiovascular and circulatory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, rat, tissues, rabbit used to study cardiovascular and circulatory health.
Preclinical study; group or assay counts reported in the full text include n=10, n=11, n=9.
0.2 L/min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 3%, 0.2 L/min, 0.3%.
Inhaled molecular H₂ at 0.3%; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 3%, 0.2 L/min, 0.3%. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “Olfactomedin 4 expression was also relatively higher in the hydrogen group than in the reperfusion group, although the differences were not significant; B: Hes1…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36632117 · DOI: 10.4240/wjgs.v14.i12.1329
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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