Hydrogenology
Hydrogenology editorial study record

Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen

Franceschelli S et al. · J Cell Mol Med. 2018;22(5):2750–2759.

HumanOther formsPublished 2018
Study record, not medical adviceThis page reports one source and Hydrogenology’s source-text extraction. It does not establish that molecular hydrogen is effective, safe or appropriate for any person. Human, animal and laboratory evidence must not be treated as equivalent.
Source and classification

What kind of evidence is this?

Evidence stream

Human

Reported design

Randomized adjunctive-treatment parallel study

Research topic

Gastrointestinal health

Administration classification

Other forms

Study result signal

Not reported in this record.

Outcome type

Not reported in this record.

Reported in the source

Methods at a glance

Population or model

Adults with gastroesophageal reflux disease

Sample

84 participants: PPI plus H₂-rich water n=44; PPI plus tap water n=40

Duration

3 months

Intervention

Pantoprazole plus 1,500 mL/day electrolyzed reduced water containing dissolved H₂

Hydrogen form

H₂ dissolved in electrolyzed reduced water — H₂ only, not Brown’s gas.

H₂ specification

The complete article does not report a numeric dissolved-H₂ concentration. The device allowed pH 8.10–11.60 and ORP −200 to −800 mV, but these do not substitute for an H₂ concentration.

H₂ flow

Not applicable — oral water, not gas inhalation.

O₂ delivered with H₂

No O₂ was co-delivered as part of the intervention.

Comparator

Pantoprazole plus 1,500 mL/day tap water

Reported, not endorsed

Outcomes and reported result

Outcomes measured

GERD health-related quality of life and oxidative/nitrosative-stress laboratory measures

Reported result

Symptoms and several redox measures improved in both groups, with some changes reported as greater after electrolyzed water. All participants also received active PPI treatment.

Results-extraction completeness

The complete open-access article was checked for intervention preparation, participant flow, outcome tables, funding and conflicts. A numeric H₂ concentration is not reported in the article.

A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.

Interpretation limits

Cautions and applicability

Design and reporting cautions

Adjunctive design with active PPI in both groups, questionnaire and laboratory outcomes, and no reported numeric H₂ concentration. The device was supplied by a named provider; authors declared no conflicts and reported public funding.

Applies directly to

Adults with GERD receiving pantoprazole under the study protocol; not H₂-water monotherapy.

Preliminary appraisal framework

Not reported in this record.

Preliminary risk-of-bias status

Not reported in this record.

Appraisal rationale

Not reported in this record.

No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.

Provenance

Sources and record status

Identifiers

PMID: 29512923 · DOI: 10.1111/jcmm.13569

Publisher access

Open-access full text is available through PMC and the publisher.

Extraction basis

Open-access PMC and publisher full texts plus PubMed bibliographic record.

Record revision

2026-08-10

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