Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen
Franceschelli S et al. · J Cell Mol Med. 2018;22(5):2750–2759.
Study at a glance
Human
Adults with gastroesophageal reflux disease
Pantoprazole plus 1,500 mL/day electrolyzed reduced water containing dissolved H₂ · The complete article does not report a numeric dissolved-H₂ concentration. The device allowed pH 8.10–11.60 and ORP −200 to −800 mV, but these do not substitute for an H₂ concentration.
3 months
Symptoms and several redox measures improved in both groups, with some changes reported as greater after electrolyzed water. All participants also received active PPI treatment.
Adjunctive design with active PPI in both groups, questionnaire and laboratory outcomes, and no reported numeric H₂ concentration. The device was supplied by a named provider; authors declared no conflicts and reported public funding.
What kind of evidence is this?
Human
Randomized adjunctive-treatment parallel study
Gastrointestinal health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Adults with gastroesophageal reflux disease
84 participants: PPI plus H₂-rich water n=44; PPI plus tap water n=40
3 months
Pantoprazole plus 1,500 mL/day electrolyzed reduced water containing dissolved H₂
H₂ dissolved in electrolyzed reduced water — H₂ only, not Brown’s gas.
The complete article does not report a numeric dissolved-H₂ concentration. The device allowed pH 8.10–11.60 and ORP −200 to −800 mV, but these do not substitute for an H₂ concentration.
Pantoprazole plus 1,500 mL/day tap water
Outcomes and reported result
GERD health-related quality of life and oxidative/nitrosative-stress laboratory measures
Symptoms and several redox measures improved in both groups, with some changes reported as greater after electrolyzed water. All participants also received active PPI treatment.
The complete open-access article was checked for intervention preparation, participant flow, outcome tables, funding and conflicts. A numeric H₂ concentration is not reported in the article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Adjunctive design with active PPI in both groups, questionnaire and laboratory outcomes, and no reported numeric H₂ concentration. The device was supplied by a named provider; authors declared no conflicts and reported public funding.
Adults with GERD receiving pantoprazole under the study protocol; not H₂-water monotherapy.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 29512923 · DOI: 10.1111/jcmm.13569
Open-access full text is available through PMC and the publisher.
Open-access PMC and publisher full texts plus PubMed bibliographic record.
10 August 2026
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