Administration of Hydrogen-Rich Saline in Mice with Allogeneic Hematopoietic Stem-Cell Transplantation
Yuan L, Chen X, Qian L, Shen J, Cai J. · Medical science monitor : international medical journal of experimental and clinical research. 2015;21:749-754.
Study at a glance
Preclinical
mice, cells, tissue, cell used to study critical care and ischemia-reperfusion.
Full text reports H₂ dissolved in saline. Detected intervention quantities or schedules: 0.9%, 0.6 mmol/L, 5 ml/kg, 30 days. · H₂-related quantities reported in the intervention passages: 0.9%, 0.6 mmol/L, 5 ml/kg, 30 days. Values are not combined across different experimental arms.
30 days
Article-reported result excerpt (24 words maximum): “Forty percent of aGVHD mice with physiologic saline treatment survived to the 18^th day after BMT, and 90% of the mice with hydrogen-rich saline…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Critical care and ischemia-reperfusion
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, cells, tissue, cell used to study critical care and ischemia-reperfusion.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
30 days
Full text reports H₂ dissolved in saline. Detected intervention quantities or schedules: 0.9%, 0.6 mmol/L, 5 ml/kg, 30 days.
H₂ dissolved in saline — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.9%, 0.6 mmol/L, 5 ml/kg, 30 days. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “Forty percent of aGVHD mice with physiologic saline treatment survived to the 18^th day after BMT, and 90% of the mice with hydrogen-rich saline…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies to the reported animal, cell or tissue model for critical care and ischemia-reperfusion, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 25763677 · DOI: 10.12659/msm.891338
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
29 September 2026
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