Hydrogen inhalation ameliorates lung inflammation in mice with asthma
Li H et al. · Eur J Med Res. 2025;30:1024.
Study at a glance
Preclinical
Female C57BL/6 mice sensitized and challenged with ovalbumin
Whole-body exposure to 15% H₂ in air for 1 hour daily over 7 consecutive days · 15% H₂ in air at a reported total chamber flow of 4 L/min.
One hour daily for 7 consecutive days
The article reports lower airway responsiveness, inflammation, IgE and MDA and higher SOD and regulatory-cytokine expression with H₂.
Small preclinical asthma model. The 600 mL/min figure is a calculated H₂ component of chamber flow, not a separately measured animal inspired-flow value.
What kind of evidence is this?
Preclinical
Randomized mouse ovalbumin-asthma experiment
Respiratory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Female C57BL/6 mice sensitized and challenged with ovalbumin
32 mice; the article describes groups of eight
One hour daily for 7 consecutive days
Whole-body exposure to 15% H₂ in air for 1 hour daily over 7 consecutive days
H₂ diluted in air — not Brown’s gas.
15% H₂ in air at a reported total chamber flow of 4 L/min.
Ovalbumin-asthma mice exposed to ambient atmosphere, plus non-asthmatic controls
Outcomes and reported result
Airway responsiveness, type-2 cytokines, IgE, regulatory cytokines, lung histology, MDA and SOD
The article reports lower airway responsiveness, inflammation, IgE and MDA and higher SOD and regulatory-cytokine expression with H₂.
Allocation, concentration, total flow, timing, outcomes, funding and conflicts checked in the open-access full text.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Small preclinical asthma model. The 600 mL/min figure is a calculated H₂ component of chamber flow, not a separately measured animal inspired-flow value.
Ovalbumin-induced airway inflammation in mice, not clinical asthma.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 41146240 · DOI: 10.1186/s40001-025-03296-7
Open-access full text is available through PMC and the publisher.
Open-access publisher/PMC full text and PubMed record; no retraction or expression of concern was shown in the checked records on 7 August 2026.
10 August 2026
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