Alleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes
Zhang X, Lu X, Li F, Gu H, Cheng X, Tang J, Zhang X, Jiang J, Feng L, Li X. · Journal of thoracic disease. 2025;17(8):6151-6162.
Study at a glance
Human
Human participants studied for exercise and recovery; aged 15–27 years. See eligibility criteria in the linked full text.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 66.7%, 33.3%, 0%, 3 L/min, 20 minutes, 7.5%, 21%, 60%. · H₂-related quantities reported in the intervention passages: 66.7%, 33.3%, 0%, 3 L/min, 20 minutes, 7.5%, 21%, 60%. Values are not combined across different experimental arms.
3 L/min
Article-reported result excerpt (24 words maximum): “The MDA levels were significantly reduced in both intervention groups, especially in the hydrogen group. *, P<0.05 versus control group.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Randomized controlled study
Exercise and recovery
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for exercise and recovery; aged 15–27 years. See eligibility criteria in the linked full text.
Human study; the full text reports 24 participants, with group/assay counts including n=14, n=9, n=8, n=6.
3 L/min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 66.7%, 33.3%, 0%, 3 L/min, 20 minutes, 7.5%, 21%, 60%.
Inhaled molecular H₂ at 66.7%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 66.7%, 33.3%, 0%, 3 L/min, 20 minutes, 7.5%, 21%, 60%. Values are not combined across different experimental arms.
2001 mL/min H₂, calculated from 66.7% H₂ and 3000 mL/min total flow reported in the full text.
33.3% O₂; 999 mL/min O₂ calculated from the reported total flow.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “The MDA levels were significantly reduced in both intervention groups, especially in the hydrogen group. *, P<0.05 versus control group.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this exercise and recovery article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 40950921 · DOI: 10.21037/jtd-2025-1278
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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