Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study
Zhao Z, Ji H, Zhao Y, Liu Z, Sun R, Li Y, Ni T. · Frontiers in endocrinology. 2022;13:1114221.
Study at a glance
Human
Human participants studied for metabolic and lipid health. See eligibility criteria in the linked full text.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 100%. · H₂-related quantities reported in the intervention passages: 100%. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “After 6-month treatment, both the levels of HbA1c and FPG decreased in HI group (-0.94%; 95% CI -1.04 to -0.85 and -22.7 mg/dL; 95%…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
What kind of evidence is this?
Human
Retrospective human study
Metabolic and lipid health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for metabolic and lipid health. See eligibility criteria in the linked full text.
Human study; the full text reports 603 patients, with group/assay counts including n=544.
Multiple article-specific time points; see the linked full methods.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 100%.
Inhaled molecular H₂ at 100%; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 100%. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “After 6-month treatment, both the levels of HbA1c and FPG decreased in HI group (-0.94%; 95% CI -1.04 to -0.85 and -22.7 mg/dL; 95%…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The full article contains a conflict, commercial-support or supplied-product declaration; consult the source wording.
Applies only to the population and protocol reported in this metabolic and lipid health article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36743938 · DOI: 10.3389/fendo.2022.1114221
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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