Antioxidant effects of continuous intake of electrolyzed hydrogen water in healthy adults
Mizuno K, Watanabe K, Yamano E, Ebisu K, Tajima K, Nojima J, Ohsaki Y, Kabayama S, Watanabe Y. · Heliyon. 2022;8(11):e11853.
Study at a glance
Human
Human participants studied for metabolic and lipid health. See eligibility criteria in the linked full text.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 300 ppb, 323 ppb, 7%, 894 ppb, 540 ppb, 40%. · H₂-related quantities reported in the intervention passages: 300 ppb, 323 ppb, 7%, 894 ppb, 540 ppb, 40%. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “Error bars represent standard deviations. ∗∗∗ P < 0.001, ∗ P < 0.05, significant difference between the corresponding values..” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Human interventional or observational study
Metabolic and lipid health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for metabolic and lipid health. See eligibility criteria in the linked full text.
Human study; the article does not state one consolidated sample total, so no total is inferred.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 300 ppb, 323 ppb, 7%, 894 ppb, 540 ppb, 40%.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 300 ppb, 323 ppb, 7%, 894 ppb, 540 ppb, 40%. Values are not combined across different experimental arms.
Placebo or matched control reported in the full article.
Outcomes and reported result
clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, metabolic laboratory measures, cardiovascular measures, respiratory measures
Article-reported result excerpt (24 words maximum): “Error bars represent standard deviations. ∗∗∗ P < 0.001, ∗ P < 0.05, significant difference between the corresponding values..” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this metabolic and lipid health article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36468139 · DOI: 10.1016/j.heliyon.2022.e11853
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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