Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study
Chiu SH, Douglas FL, Chung JR, Wang KY, Chu CF, Chou HY, Huang WC, Wang TY, Chen WW, Shen MC, Liu FC, Hsiao PJ. · Frontiers in nutrition. 2023;10:1198524.
What kind of evidence is this?
Human
Prospective human study
Metabolic and lipid health
H₂-rich water
Not reported in this record.
Not reported in this record.
Methods at a glance
Human participants studied for metabolic and lipid health. See eligibility criteria in the linked full text.
Human study; the full text reports 16 patients, with group/assay counts including n=5, n=6, n=16.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water plus an oral H₂-generating preparation. Detected intervention quantities or schedules: 0.6 mM, 200 mL.
H₂ dissolved in drinking water plus an oral H₂-generating preparation — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.6 mM, 200 mL. Values are not combined across different experimental arms.
Not applicable — no inhaled H₂ intervention was identified in the full article.
No inhaled O₂ co-delivery was identified for this non-inhalation intervention.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “No significant differences in body weight were observed [[Figure 1A]; t (16) = 0.57, p = 0.57].” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Human evidence; design, sample size and comparator limit interpretation. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies only to the population and protocol reported in this metabolic and lipid health article.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 37521410 · DOI: 10.3389/fnut.2023.1198524
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10