Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study
Chiu SH, Douglas FL, Chung JR, Wang KY, Chu CF, Chou HY, Huang WC, Wang TY, Chen WW, Shen MC, Liu FC, Hsiao PJ. · Frontiers in nutrition. 2023;10:1198524.
Study at a glance
Human
Human participants studied for metabolic and lipid health. See eligibility criteria in the linked full text.
Full text reports H₂ dissolved in drinking water plus an oral H₂-generating preparation. Detected intervention quantities or schedules: 0.6 mM, 200 mL. · H₂-related quantities reported in the intervention passages: 0.6 mM, 200 mL. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “No significant differences in body weight were observed [[Figure 1A]; t (16) = 0.57, p = 0.57].” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Human
Prospective human study
Metabolic and lipid health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for metabolic and lipid health. See eligibility criteria in the linked full text.
Human study; the full text reports 16 patients, with group/assay counts including n=5, n=6, n=16.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water plus an oral H₂-generating preparation. Detected intervention quantities or schedules: 0.6 mM, 200 mL.
H₂ dissolved in drinking water plus an oral H₂-generating preparation — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.6 mM, 200 mL. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “No significant differences in body weight were observed [[Figure 1A]; t (16) = 0.57, p = 0.57].” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies only to the population and protocol reported in this metabolic and lipid health article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 37521410 · DOI: 10.3389/fnut.2023.1198524
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.