Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial
Wu F et al. · Heliyon. 2024;10(16):e36401.
Study at a glance
Human
Adults with hyperuricemia
Low dose: two 330 mL H₂-water bottles plus one ordinary-water bottle daily. High dose: three 330 mL H₂-water bottles daily. · H₂ concentration at least 4.66 mg/L. The high-dose group received approximately 4.61 mg H₂/day.
8 weeks; assessments at weeks 4 and 8
Uric acid fell within the high-dose group from 488.2 to 446.8 μmol/L at week 8. However, the proportions achieving at least a 10% reduction did not differ significantly between placebo, low-dose and high-dose groups.
The highlighted reduction is a within-group result. The categorical responder comparisons between groups were not significant, so superiority over placebo is not established by that analysis.
What kind of evidence is this?
Human
Randomized placebo-controlled three-arm trial
Metabolic and lipid health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Adults with hyperuricemia
100 completed: placebo n=32, low-dose n=35, high-dose n=33
8 weeks; assessments at weeks 4 and 8
Low dose: two 330 mL H₂-water bottles plus one ordinary-water bottle daily. High dose: three 330 mL H₂-water bottles daily.
H₂ dissolved in water — H₂ only, not Brown’s gas.
H₂ concentration at least 4.66 mg/L. The high-dose group received approximately 4.61 mg H₂/day.
Three 330 mL bottles/day of ordinary drinking water
Outcomes and reported result
Blood uric acid, dose and time response, safety
Uric acid fell within the high-dose group from 488.2 to 446.8 μmol/L at week 8. However, the proportions achieving at least a 10% reduction did not differ significantly between placebo, low-dose and high-dose groups.
Methods, main results and trial registration checked in the free full text; independent appraisal remains incomplete.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
The highlighted reduction is a within-group result. The categorical responder comparisons between groups were not significant, so superiority over placebo is not established by that analysis.
Adults with hyperuricemia meeting this trial’s criteria.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39258191 · DOI: 10.1016/j.heliyon.2024.e36401
Open-access article.
Free full text on PMC and publisher page; identifiers cross-checked in PubMed.
10 August 2026
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