Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity
Terawaki H, Hayashi Y, Zhu WJ, Matsuyama Y, Terada T, Kabayama S, Watanabe T, Era S, Sato B, Nakayama M. · 2013.
Study at a glance
Human
Six adults receiving peritoneal dialysis.
A single peritoneal-dialysis session using hydrogen-enriched dialysate. · The article reports dialysate preparation and measured exposure; no inhaled gas was used.
Single administration with serial sampling over the dialysis session.
The report describes changes in albumin redox-state measures after the hydrogen-enriched dialysate and no immediate detrimental effect in this small pilot.
Six-person uncontrolled pilot with surrogate outcomes and no evidence about clinical events.
What kind of evidence is this?
Human
Uncontrolled acute pilot study
Kidney and urinary health
Other forms
Exploratory within-person biomarker signal.
Short-term laboratory surrogate and safety observations.
Methods
Six adults receiving peritoneal dialysis.
6 patients.
Single administration with serial sampling over the dialysis session.
A single peritoneal-dialysis session using hydrogen-enriched dialysate.
H₂ dissolved in dialysis solution.
The article reports dialysate preparation and measured exposure; no inhaled gas was used.
Within-person measurements before and after exposure; no concurrent control group.
Outcomes and reported result
Peritoneal and plasma redox-state markers and immediate tolerability.
The report describes changes in albumin redox-state measures after the hydrogen-enriched dialysate and no immediate detrimental effect in this small pilot.
The full article was checked for methods, intervention details, outcomes, positive and null findings, funding and conflicts. This record does not imply medical efficacy.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Six-person uncontrolled pilot with surrogate outcomes and no evidence about clinical events.
Peritoneal-dialysis patients under this single-session protocol.
ROBINS-I — preliminary
Serious concerns
No concurrent comparator, very small sample and short biomarker follow-up create serious confounding and imprecision.
Selection and allocation checked · Confounding and co-interventions remain possible · Missing observations checked where reported · Outcome measurement varies by endpoint · Selective reporting cannot be excluded
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 23816239 · DOI: 10.1186/2045-9912-3-14
A free full article is available through PubMed Central.
Official PubMed Central full article and PubMed bibliographic record; source identity, methods, intervention, results, funding and conflicts checked 10 August 2026.
10 August 2026
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