Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain.
Yufune S, Satoh Y, Akai R, Yoshinaga Y, Kobayashi Y, Endo S, Kazama T. · 2016.
Study at a glance
Preclinical
Developing mice exposed to sevoflurane and related pathway interventions.
Molecular hydrogen administered during the sevoflurane neurotoxicity protocol. · Exposure details were checked in the full methods; no clinical dose is inferred.
Acute neonatal exposure with later behavioral assessment.
Hydrogen restored ERK phosphorylation and attenuated sevoflurane-associated apoptosis in the reported developing-brain model.
Mechanistic animal study with multiple pathway interventions; it does not establish pediatric anesthetic benefit.
What kind of evidence is this?
Preclinical
Controlled neonatal-mouse mechanistic study
Other neurological conditions
Other forms
Positive preclinical mechanistic signal.
Animal molecular, cell-death and behavioral outcomes.
Methods
Developing mice exposed to sevoflurane and related pathway interventions.
Animal groups and assay-specific counts were checked in the full article.
Acute neonatal exposure with later behavioral assessment.
Molecular hydrogen administered during the sevoflurane neurotoxicity protocol.
Article-specified molecular H₂ exposure.
Exposure details were checked in the full methods; no clinical dose is inferred.
Sevoflurane, pathway-inhibitor and hydrogen intervention comparisons.
Outcomes and reported result
ERK phosphorylation, neuronal apoptosis and later behavioral measures.
Hydrogen restored ERK phosphorylation and attenuated sevoflurane-associated apoptosis in the reported developing-brain model.
The full article was checked for methods, intervention details, outcomes, positive and null findings, funding and conflicts. This record does not imply medical efficacy.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Mechanistic animal study with multiple pathway interventions; it does not establish pediatric anesthetic benefit.
The reported neonatal-mouse sevoflurane model only.
SYRCLE animal-study tool — preliminary
Some concerns
Controlled interventions were used, but concealment, assessor blinding and multiplicity handling were unclear.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 26905012 · DOI: 10.1038/srep21859
A free full article is available through PubMed Central.
Official PubMed Central full article and PubMed bibliographic record; source identity, methods, intervention, results, funding and conflicts checked 10 August 2026.
10 August 2026
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