Oral Administration of Si-Based Agent Attenuates Oxidative Stress and Ischemia-Reperfusion Injury in a Rat Model: A Novel Hydrogen Administration Method.
Kawamura M, Imamura R, Kobayashi Y, Taniguchi A, Nakazawa S, Kato T, Namba-Hamano T, Abe T, Uemura M, Kobayashi H, Nonomura N. · 2020.
Study at a glance
Preclinical
Rats with renal ischemia-reperfusion injury.
Oral nano-silicon particles that generate molecular hydrogen after reacting with water. · Nano-silicon and larger-particle silicon arms were compared; systemic H₂ dose was not directly measured.
Outcomes through 72 hours after ischemia-reperfusion.
Nano-silicon was associated with lower renal-injury and oxidative measures and altered inflammatory or apoptotic pathways versus untreated injury.
The intervention is a hydrogen-generating silicon product; particle-size and material effects cannot be assigned solely to H₂.
What kind of evidence is this?
Preclinical
Controlled rat kidney ischemia-reperfusion study
Kidney and urinary health
Other forms
Positive preclinical signal for the nano-silicon condition.
Animal renal-function, tissue and molecular outcomes.
Methods
Rats with renal ischemia-reperfusion injury.
Four experimental groups; animal and assay counts were checked in the full article.
Outcomes through 72 hours after ischemia-reperfusion.
Oral nano-silicon particles that generate molecular hydrogen after reacting with water.
Oral H₂-generating silicon agent.
Nano-silicon and larger-particle silicon arms were compared; systemic H₂ dose was not directly measured.
Sham, untreated injury, nano-silicon and large-silicon groups.
Outcomes and reported result
Creatinine, urine protein, oxidative markers, inflammation, apoptosis and transcriptomics.
Nano-silicon was associated with lower renal-injury and oxidative measures and altered inflammatory or apoptotic pathways versus untreated injury.
The full article was checked for methods, intervention details, outcomes, positive and null findings, funding and conflicts. This record does not imply medical efficacy.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
The intervention is a hydrogen-generating silicon product; particle-size and material effects cannot be assigned solely to H₂.
The reported rat kidney-injury and silicon-agent protocol only.
SYRCLE animal-study tool — preliminary
Some concerns
Multiple controlled groups were present, but concealment, blinded assessment and material-specific confounding were unclear.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 32266279 · DOI: 10.3389/fmed.2020.00095
A free full article is available through PubMed Central.
Official PubMed Central full article and PubMed bibliographic record; source identity, methods, intervention, results, funding and conflicts checked 10 August 2026.
10 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.