Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete
Javorac D, Stajer V, Ostojic SM. · 2019.
Study at a glance
Human
A 24-year-old professional athlete after mild traumatic brain injury.
Repeated buccal administration of a hydrogen-producing blend after injury. · Article-specific product and administration schedule; systemic hydrogen dose was not measured.
Intensive treatment during the first 24 hours with short follow-up.
The case describes improvement in symptoms and test performance after treatment, but no causal comparison is possible.
Single uncontrolled case, spontaneous recovery and concurrent concussion care prevent attribution to the product.
What kind of evidence is this?
Human
Single-patient case report
Other neurological conditions
Other forms
Indeterminate for molecular hydrogen.
Clinical observations and functional tests in one patient.
Methods
A 24-year-old professional athlete after mild traumatic brain injury.
1 patient.
Intensive treatment during the first 24 hours with short follow-up.
Repeated buccal administration of a hydrogen-producing blend after injury.
Oral transmucosal H₂-generating preparation.
Article-specific product and administration schedule; systemic hydrogen dose was not measured.
No control; clinical course after treatment.
Outcomes and reported result
Symptoms, cognitive or balance testing and recovery observations.
The case describes improvement in symptoms and test performance after treatment, but no causal comparison is possible.
The full article was checked for methods, intervention details, outcomes, positive and null findings, funding and conflicts. This record does not imply medical efficacy.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Single uncontrolled case, spontaneous recovery and concurrent concussion care prevent attribution to the product.
This individual case only.
JBI case-report checklist — preliminary
Critical concerns
No comparator, one participant and high susceptibility to regression, co-intervention and selective reporting.
Selection and allocation checked · Confounding and co-interventions remain possible · Missing observations checked where reported · Outcome measurement varies by endpoint · Selective reporting cannot be excluded
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 32595937 · DOI: 10.12688/f1000research.19739.1
A free full article is available through PubMed Central.
Official PubMed Central full article and PubMed bibliographic record; source identity, methods, intervention, results, funding and conflicts checked 10 August 2026.
10 August 2026
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