Hydrogen-Rich Water as a Novel Therapeutic Strategy for the Affective Disorders Linked with Chronic Neuropathic Pain in Mice
Martínez-Serrat M, Martínez-Martel I, Coral-Pérez S, Bai X, Batallé G, Pol O. · Antioxidants (Basel, Switzerland). 2022;11(9):1826.
Study at a glance
Preclinical
mice, mouse, tissues, rabbit used to study other neurological conditions.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 0.3 mM, 7 days, 4 days, 10 mL/kg. · H₂-related quantities reported in the intervention passages: 0.3 mM, 7 days, 4 days, 10 mL/kg. Values are not combined across different experimental arms.
7 days
Article-reported result excerpt (24 words maximum): “The results showed: (i) the inhibitory effects of the repetitive treatment with HRW on the allodynia and hyperalgesia provoked by CCI; (ii) the anxiolytic…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Other neurological conditions
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, mouse, tissues, rabbit used to study other neurological conditions.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
7 days
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 0.3 mM, 7 days, 4 days, 10 mL/kg.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.3 mM, 7 days, 4 days, 10 mL/kg. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, neurological or behavioral measures
Article-reported result excerpt (24 words maximum): “The results showed: (i) the inhibitory effects of the repetitive treatment with HRW on the allodynia and hyperalgesia provoked by CCI; (ii) the anxiolytic…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36139900 · DOI: 10.3390/antiox11091826
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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