Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
Li Z, Chen K, Shao Q, Lu H, Zhang X, Pu Y, Sun X, He H, Cao L. · Journal of Neuroinflammation. 2023;20:26.
Study at a glance
Preclinical
Mouse experimental autoimmune encephalomyelitis, restraint and lysolecithin models plus cell experiments.
AIN93G feed containing 0.5% magnesium hydride nanoparticles. · Magnesium and hydrogen effects were not fully separable.
Up to 30 days in the EAE experiment, with model-specific schedules elsewhere.
EAE and selected behavioral and inflammatory outcomes improved, but oligodendrocyte differentiation and remyelination outcomes were not improved in the tested models.
Preclinical, multi-model evidence; magnesium-hydride and hydrogen effects cannot be separated.
What kind of evidence is this?
Preclinical
Controlled mouse and cell study
Other neurological conditions
Other forms
Mixed preclinical signal.
Animal functional, disease-score, tissue and biomarker outcomes.
Methods
Mouse experimental autoimmune encephalomyelitis, restraint and lysolecithin models plus cell experiments.
Multiple experiments; the EAE comparison included 12 supplemented and 11 control-model mice at analysis.
Up to 30 days in the EAE experiment, with model-specific schedules elsewhere.
AIN93G feed containing 0.5% magnesium hydride nanoparticles.
Hydrogen generated by magnesium hydride; not Brown's gas.
Magnesium and hydrogen effects were not fully separable.
Standard feed and model-specific control conditions.
Outcomes and reported result
EAE incidence and score, anxiety/depression-like behavior, inflammation, oxidative stress and remyelination.
EAE and selected behavioral and inflammatory outcomes improved, but oligodendrocyte differentiation and remyelination outcomes were not improved in the tested models.
The full article, multiple models, methods and positive and null findings were checked.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical, multi-model evidence; magnesium-hydride and hydrogen effects cannot be separated.
The reported mouse and cell neuroinflammation models.
SYRCLE animal-study tool — preliminary
Some concerns
Model-specific attrition and unclear allocation concealment and assessor blinding.
Randomization/allocation reporting is limited · Blinding of personnel is unclear · Attrition is incompletely reported in places · Blinding of outcome assessors is unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 36710351 · DOI: 10.1186/s12974-023-02696-y
Free full article in PubMed Central.
PubMed record and PubMed Central full text; extraction checked 9 August 2026.
10 August 2026
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